Bioplatforms Australia builds research capabilities and expertise in the specialist fields of genomics, proteomics, metabolomics and bioinformatics.
BPA enables Australian life science research by investing in state-of-the-art infrastructure and projects that build 'omic datasets relevant to Australian scientific challenges.
The Queensland nodes of Metabolomics and Proteomics are housed at The University of Queensland's Australian Institute for Bioengineering and Nanotechnology.
The Queensland Node of Metabolomics Australia
Metabolomics Australia offers services to all science researchers in academia and industry. We combine high-throughput analytical technologies for the detection and quantification of metabolites
in biological systems with the application of bioinformatics tools for data analysis, mining and interpretation.
Metabolomics Services
Targeted/Quantitative
- LCMS Absolute quantitation of central carbon metabolites, vitamins, short-chain fatty acids, nucleotides/nucleosides.
- UHPLC: Amino acids, organic acids, sugars, short chain fatty acids, terpenoids, aromatic compounds.
- GC-MS: Target metabolites or metabolite classes are analysed quantitatively relative to
- authentic standards providing absolute concentration of each metabolite per fresh weight
- of material.
Untargeted
- GC-MS (semi-quantitative): Identification of organic acids, fatty acids, sterols, amino acids,
- sugars, sugar phosphates/alcohols, hydrocarbons, terpenes.
Data analysis
- Data processing workflows
We combine complementary analytical and informatics platforms to detect the response of metabolites to genetic and environmental stimuli.
Our node specialises in servicing the industrial biotechnology sector
The Queensland Node of Proteomics Australia
The Queensland Node of Proteomics Australia offers high throughput quantitative proteomics services to all life science researchers. Services are offered through a consortium of Australian universities and research institutes with world class facilities.
Proteomics Services
Sample Preparation
- Automated Sample preparation
Protein Identification
- By Data Dependant Analysis
Protein quantification
- By Data Dependent Analysis
- By Data Independent Analysis
- By Isobaric Tag Analysis
Protein modification Analysis
- By phosphorylation, Γ carboxylation
Data analysis
- Data processing workflows
Our New ThermoFisher Q-Exactive HF-X offers a new standard in sensitivity, performance and productivity.
Systems Biology
The “4th generation of biotechnology” is concerned with understanding and manipulating cellular behaviour at a system level. Dedicated data science and bioinformatics services that offer data processing to enable the use of ‘omics to understand complex links between genotype and phenotype.
Systems Biology Services
Our service facilitates a variety of metabolic engineering applications in model and non-model organisms through:
Modelling
- Modelling and analysis of small to large data sets
- Identification of metabolically optimal pathways for targeted products
Molecular phenomics
- Phenotype prediction through stoichiometric and kinetic modelling
- Leveraging ‘omics data to predict rate limiting metabolic reactions
- Phenotypic characterization of high-performing mutant strains resulting from random mutagenesis or evolutionary approaches
Data Analysis
- Data processing workflows
We provide systems biology platforms that can be used to answer a range of biological questions. Examples include phenotypic changes in response to a stimulus on a molecular level to strain engineering and design for industrial biotechnology applications.
Integration of multiomics data using metabolic modelling.
