Ataxia-Telangiectasia (A-T) is caused by mutations in the ATM kinase, a protein involved in DNA break repair, oxidative stress regulation and metabolism.
Replacing a defective gene via AAV mediated gene therapy is a powerful therapeutic approach. This project will develop and test safer gene therapy approaches in pre-clinical human brain organoid models.
For those interested in: stem cell ageing and regenerative engineering
Human brain development can be severely impacted by a lack of oxygen perinatally. This project will study the molecular and cellular processes that are responsible in human stem cell derived brain organoid models.
For those interested in: Stem cell ageing and regenerative engineering
Senescnece is an important driver of ageing related brain diseases. This project will use genetic and engineered brain organoid ageing models to identify and test better and more targetd senolytics and senomorphic compounds.
Tiny brains grown in a lab could help The University of Queensland (UQ) researchers find a treatment for a rare hereditary disease and, in the process, unlock therapies for a range of other neurological disorders.
Wounds that heal without leaving a scar, and research to prevent developmental impairments in children are two crucial Australian Institute for Bioengineering and Nanotechnology (AIBN) projects that have been backed under the latest Ideas Grants funding round.
Tiny ‘live’ brain models are being used at The University of Queensland to study a condition causing high-functioning young people with Down Syndrome to suddenly regress.