Group publications

2023

(69) Wang, Y.; Wu, Z.; Azad, F.; Zhu, Y.; Wang, L.; Hawker, C.; Whittaker, A.; Forsyth, M.; ZHANG, C. The Fluorine Toolbox: from Molecular Design to Advanced Batteries. 2023. DOI: 10.26434/chemrxiv-2023-zj9ld.

(68) Chen, Y.; Mickel, P.; Pei, H.; Wen, Y.; Guan, X.; Wang, Y.; Wang, X.; Mhtachem, O. A.; Zhang, C.; Nie, H.; et al. Bioinspired Separator with Ion-Selective Nanochannels for Lithium Metal Batteries. ACS Applied Materials & Interfaces 2023. DOI: 10.1021/acsami.3c01311.

2022

(67) Zhang, C.; Yan, K.; Fu, C.; Peng, H.; Hawker, C. J.; Whittaker, A. K. Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation. Chem. Rev. 2022, 122 (1), 167-208. DOI: 10.1021/acs.chemrev.1c00632.

(66) Zhang, C. Fluorine in Medicinal Chemistry: In Perspective to COVID-19. ACS Omega 2022, 7 (22), 18206-18212. DOI: 10.1021/acsomega.2c01121.

(65) Yan, K.; Mu, C.; Zhang, C.; Xu, Q.; Xu, Z.; Wang, D.; Jing, X.; Meng, L. Pt nanoenzyme decorated yolk-shell nanoplatform as an oxygen generator for enhanced multi-modality imaging-guided phototherapy. J. Colloid Interface Sci. 2022, 616, 759-768.

(64) Wu, J.; Zhang, J.; Liu, Y.; Wang, J.; Zhang, C.; Yan, J.; Li, W.; Masuda, T.; Whittaker, A. K.; Zhang, A. Supramolecular Chiral Assembly of Symmetric Molecules with an Extended Conjugated Core. ACS Appl. Mater. Interfaces 2022. DOI: 10.1021/acsami.2c09752.

(63) Whittaker, A.; Zhang, C.; Tan, X. Capture of fluorinated carbon compounds. US Patent App. 17/429,217: 2022.

(62) Wang, Y.; Tan, X.; Usman, A.; Zhang, Y.; Sawczyk, M.; Král, P.; Zhang, C.; Whittaker, A. K. Elucidating the Impact of Hydrophilic Segments on 19F MRI Sensitivity of Fluorinated Block Copolymers. ACS Macro Lett. 2022, 11 (10), 1195-1201. DOI: 10.1021/acsmacrolett.2c00414.

(61) Wang, X.; Zhang, C.; Sawczyk, M.; Sun, J.; Yuan, Q.; Chen, F.; Mendes, T. C.; Howlett, P. C.; Fu, C.; Wang, Y.; et al. Ultra-stable all-solid-state sodium metal batteries enabled by perfluoropolyether-based electrolytes. Nat. Mater. 2022, 21 (9), 1057-1065. DOI: 10.1038/s41563-022-01296-0.

(60) Tao, S.; Zhang, C.; Zhang, J.; Jiao, Y.; Li, M.; Lin, W.; Ran, L.; Clement, B.; Lyu, M.; Gentle, I.; et al. A Hydrophobic and Fluorophilic Coating Layer for Stable and Reversible Aqueous Zinc Metal Anodes. Chem. Eng. J. 2022, 446, 136607. DOI: 10.1016/j.cej.2022.136607.

(59) Tan, X.; Sawczyk, M.; Chang, Y. X.; Wang, Y. Q.; Usman, A.; Fu, C. K.; Kral, P.; Peng, H.; Zhang, C.; Whittaker, A. K. Revealing the Molecular-Level Interactions between Cationic Fluorinated Polymer Sorbents and the Major PFAS Pollutant PFOA. Macromolecules 2022, 55 (3), 1077-1087. DOI: 10.1021/acs.macromol.1c02435.

(58) Tan, X.; Dewapriya, P.; Prasad, P.; Chang, Y.; Huang, X.; Wang, Y.; Gong, X.; Hopkins, T. E.; Fu, C.; Thomas, K. V.; et al. Efficient Removal of Perfluorinated Chemicals from Contaminated Water Sources Using Magnetic Fluorinated Polymer Sorbents. Angew. Chem. Int. Ed. 2022, 61 (49), e202213071. DOI: 10.1002/anie.202213071.

(57) Murphy, E. A.; Chen, Y.-Q.; Albanese, K.; Blankenship, J. R.; Abdilla, A.; Bates, M. W.; Zhang, C.; Bates, C. M.; Hawker, C. J. Efficient Creation and Morphological Analysis of ABC Triblock Terpolymer Libraries. Macromolecules 2022, 55 (19), 8875-8882. DOI: 10.1021/acs.macromol.2c01480.

2021

(56) Zhang, C.; Vigil, D. L.; Sun, D.; Bates, M. W.; Loman, T.; Murphy, E. A.; Barbon, S. M.; Song, J.-A.; Yu, B.; Fredrickson, G. H.; et al. Emergence of Hexagonally Close-Packed Spheres in Linear Block Copolymer Melts. J. Am. Chem. Soc. 2021, 143 (35), 14106-14114. DOI: 10.1021/jacs.1c03647.

(55) Usman, A.; Zhang, C.; Zhao, J.; Peng, H.; Kurniawan, N. D.; Fu, C.; Hill, D. J.; Whittaker, A. K. Tuning the thermoresponsive properties of PEG-based fluorinated polymers and stimuli responsive drug release for switchable 19 F magnetic resonance imaging. Poly. Chem. 2021, 12 (38), 5438-5448. DOI: 10.1039/D1PY00602A.

(54) Tan, X.; Zhong, J.; Fu, C.; Dang, H.; Han, Y.; Král, P.; Guo, J.; Yuan, Z.; Peng, H.; Zhang, C.; et al. Amphiphilic Perfluoropolyether Copolymers for the Effective Removal of Polyfluoroalkyl Substances from Aqueous Environments. Macromolecules 2021, 54 (7), 3447-3457. DOI: 10.1021/acs.macromol.1c00096.

2020

(53) Zhao, Q.; Zhao, W.; Zhang, C.; Wu, Y.; Yuan, Q.; Whittaker, A. K.; Zhao, X. Sodium-ion storage mechanism in triquinoxalinylene and a strategy for improving electrode stability. Energy Fuels 2020, 34 (4), 5099-5105.

(52) Zhang, C.; Moonshi, S. S.; Wang, W.; Ta, H. T.; Han, Y.; Han, F. Y.; Peng, H.; Král, P.; Rolfe, B. E.; Gooding, J. J. Correction to High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging. ACS nano 2020, 14 (10), 14245-14246. DOI: 10.1021/acsnano.0c07373.

(51) Zhang, C.; Liu, T.; Wang, W.; Bell, C. A.; Han, Y.; Fu, C.; Peng, H.; Tan, X.; Král, P.; Gaus, K.; et al. Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy. ACS Nano 2020, 14 (6), 7425-7434. DOI: 10.1021/acsnano.0c02954.

(50) Zhang, C.; Bates, M. W.; Geng, Z.; Levi, A. E.; Vigil, D.; Barbon, S. M.; Loman, T.; Delaney, K. T.; Fredrickson, G. H.; Bates, C. M.; et al. Rapid Generation of Block Copolymer Libraries Using Automated Chromatographic Separation. J. Am. Chem. Soc. 2020, 142 (21), 9843-9849. DOI: 10.1021/jacs.0c04028.

(49) Tian, F.; Chi, B.; Xu, C.; Lin, C.; Xu, Z.; Whittaker, A. K.; Zhang, C.; Li, L.; Wang, J. “Dual-Key-and-Lock” dual drug carrier for dual mode imaging guided chemo-photothermal therapy. Biomaterials Science 2020, 8 (22), 6212-6224.

(48) Qiao, R.; Fu, C.; Li, Y.; Qi, X.; Ni, D.; Nandakumar, A.; Siddiqui, G.; Wang, H.; Zhang, Z.; Wu, T. Sulfoxide‐containing polymer‐coated nanoparticles demonstrate minimal protein fouling and improved blood circulation. Adv. Sci. 2020, 7 (13), 2000406. DOI: 10.1002/advs.202000406.

(47) Lin, C.; Sun, K.; Zhang, C.; Tan, T.; Xu, M.; Liu, Y.; Xu, C.; Wang, Y.; Li, L.; Whittaker, A. Carbon dots embedded metal organic framework@ chitosan core-shell nanoparticles for vitro dual mode imaging and pH-responsive drug delivery. Microporous Mesoporous Mater. 2020, 293, 109775. DOI: 10.1016/j.micromeso.2019.109775.

(46) Fu, C.; Yu, Y.; Xu, X.; Wang, Q.; Chang, Y.; Zhang, C.; Zhao, J.; Peng, H.; Whittaker, A. K. Functional polymers as metal-free magnetic resonance imaging contrast agents. Prog. Polym. Sci. 2020, 108, 101286. DOI: 10.1016/j.progpolymsci.2020.101286.

(45) Fu, C.; Demir, B.; Alcantara, S.; Kumar, V.; Han, F.; Kelly, H.; Tan, X.; Yu, Y.; Xu, W.; Zhao, J. Low‐fouling Fluoropolymers for Bioconjugation and In Vivo Tracking. Angew. Chem. Int. Ed. 2020, 59 (12), 4729-4735. DOI: 10.1002/anie.201914119.

(44) Bates, M. W.; Barbon, S. M.; Levi, A. E.; Lewis III, R. M.; Beech, H. K.; Vonk, K. M.; Zhang, C.; Fredrickson, G. H.; Hawker, C. J.; Bates, C. M. Synthesis and self-assembly of AB n miktoarm star polymers. ACS Macro Lett. 2020, 9 (3), 396-403. DOI: 10.1021/acsmacrolett.0c00061.

(43) Barbon, S. M.; Song, J.-A.; Chen, D.; Zhang, C.; Lequieu, J.; Delaney, K. T.; Anastasaki, A.; Rolland, M.; Fredrickson, G. H.; Bates, M. W. Architecture effects in complex spherical assemblies of (AB) n-type block copolymers. ACS Macro Lett. 2020, 9 (12), 1745-1752. DOI: 10.1021/acsmacrolett.0c00704.

2019

(42) Zhang, C.; Sanchez, R. J. P.; Fu, C.; Clayden-Zabik, R.; Peng, H.; Kempe, K.; Whittaker, A. K. Importance of Thermally Induced Aggregation on 19F Magnetic Resonance Imaging of Perfluoropolyether-Based Comb-Shaped Poly(2-oxazoline)s. Biomacromolecules 2019, 20 (1), 365-374. DOI: 10.1021/acs.biomac.8b01549.

(41) Zhang, C.; Li, L.; Han, F. Y.; Yu, X.; Tan, X.; Fu, C.; Xu, Z. P.; Whittaker, A. K. Integrating Fluorinated Polymer and Manganese‐Layered Double Hydroxide Nanoparticles as pH‐activated 19F MRI Agents for Specific and Sensitive Detection of Breast Cancer. Small 2019, 15 (36), 1902309. DOI: 10.1002/smll.201902309.

(40) Yang, G.; Liu, Y.; Wang, H.; Wilson, R.; Hui, Y.; Yu, L.; Wibowo, D.; Zhang, C.; Whittaker, A. K.; Middelberg, A. P. J.; et al. Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery. Angew. Chem. Int. Ed. 2019, 58 (40), 14357-14364. DOI: https://doi.org/10.1002/anie.201908357.

(39) Yadav, P.; Zhang, C.; Whittaker, A. K.; Kailasam, K.; Shanavas, A. Magnetic and photocatalytic curcumin bound carbon nitride nanohybrids for enhanced glioma cell death. ACS Biomater. Sci. Eng. 2019, 5 (12), 6590-6601. DOI: 10.1021/acsbiomaterials.9b01224.

(38) Xiao, M.; Hao, M.; Lyu, M.; Moore, E. G.; Zhang, C.; Luo, B.; Hou, J.; Lipton‐Duffin, J.; Wang, L. Surface ligands stabilized lead halide perovskite quantum dot photocatalyst for visible light‐driven hydrogen generation. Adv. Funct. Mater. 2019, 29 (48), 1905683. DOI: 10.1002/adfm.201905683.

(37) Lin, C.; Chi, B.; Xu, C.; Zhang, C.; Tian, F.; Xu, Z.; Li, L.; Whittaker, A. K.; Wang, J. Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging. J. Mater. Chem. B 2019, 7 (42), 6612-6622.

(36) Fu, C.; Tang, J.; Pye, A.; Liu, T.; Zhang, C.; Tan, X.; Han, F.; Peng, H.; Whittaker, A. K. Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer. Biomacromolecules 2019, 20 (5), 2043-2050.

(35) Chen, A.; Er, G.; Zhang, C.; Tang, J.; Alam, M.; T. Ta, H.; Elliott, A. G.; Cooper, M. A.; Perera, J.; Swift, S. Antimicrobial anilinium polymers: The properties of poly (N, N‐dimethylaminophenylene methacrylamide) in solution and as coatings. J. Polym. Sci., Part A: Polym. Chem. 2019, 57 (18), 1908-1921.

2018

(34) Zhao, Q.; Yang, D.; Zhang, C.; Liu, X.-H.; Fan, X.; Whittaker, A. K.; Zhao, X. Tailored polyimide–graphene nanocomposite as negative electrode and reduced graphene oxide as positive electrode for flexible hybrid sodium-ion capacitors. ACS Appl. Mater. Interfaces 2018, 10 (50), 43730-43739. DOI: 10.1021/acsami.8b17171.

(33) Zhang, C.; Moonshi, S. S.; Wang, W.; Ta, H. T.; Han, Y.; Han, F. Y.; Peng, H.; Král, P.; Rolfe, B. E.; Gooding, J. J.; et al. High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging. ACS Nano 2018, 12 (9), 9162-9176. DOI: 10.1021/acsnano.8b03726.

(32) Zhang, C.; Li, W.; Liu, L.; Reid, J.; Bernardi, S.; Searles, D. J.; Peng, H.; Zhang, A.; Whittaker, A. K. Solution properties of thermally sensitive macromolecules studied by high resolution NMR and MD simulations. In Abstracts of Papers of the American Chemical Society, 2018; AMER CHEMICAL SOC: Vol. 255.

(31) Zhang, C.; Kim, D. S.; Lawrence, J.; Hawker, C. J.; Whittaker, A. K. Elucidating the impact of molecular structure on the 19F NMR dynamics and mri performance of fluorinated oligomers. ACS Macro Lett. 2018, 7 (8), 921-926. DOI: 10.1021/acsmacrolett.8b00433.

(30) Zhang, C.; Ferenz, K. Nano-Bio-imaging and therapeutic nanoparticles. J. Nanosci. Nanomed. 2018, 2 (1), 19-20.

(29) Truong, N. P.; Zhang, C.; Nguyen, T. A.; Anastasaki, A.; Schulze, M. W.; Quinn, J. F.; Whittaker, A. K.; Hawker, C. J.; Whittaker, M. R.; Davis, T. P. Overcoming surfactant-induced morphology instability of noncrosslinked diblock copolymer nano-objects obtained by RAFT emulsion polymerization. ACS Macro Lett. 2018, 7 (2), 159-165.

(28) Qiao, R.; Esser, L.; Fu, C.; Zhang, C.; Hu, J.; Ramírez-Arcía, P.; Li, Y.; Quinn, J. F.; Whittaker, M. R.; Whittaker, A. K. Bioconjugation and fluorescence labeling of iron oxide nanoparticles grafted with bromomaleimide-terminal polymers. Biomacromolecules 2018, 19 (11), 4423-4429. DOI: 10.1021/acs.biomac.8b01282.

(27) Önal, E.; Zhang, C.; Davarcı, D.; İşci, Ü.; Pilet, G.; Whittaker, A. K.; Dumoulin, F. Cyclotriphosphazene, a scaffold for 19F MRI contrast agents. Tetrahedron Lett. 2018, 59 (6), 521-523. DOI: 10.1016/j.tetlet.2017.12.032.

(26) Moonshi, S. S.; Zhang, C.; Peng, H.; Puttick, S.; Rose, S.; Fisk, N. M.; Bhakoo, K.; Stringer, B. W.; Qiao, G. G.; Gurr, P. A. A unique 19 F MRI agent for the tracking of non phagocytic cells in vivo. Nanoscale 2018, 10 (17), 8226-8239. DOI: 10.1039/c8nr00703a.

(25) Liu, Y.; Zhang, C.; Xu, C.; Lin, C.; Sun, K.; Wang, J.; Chen, X.; Li, L.; Whittaker, A. K.; Xu, H.-B. Controlled synthesis of up-conversion luminescent Gd/Tm-MOFs for pH-responsive drug delivery and UCL/MRI dual-modal imaging. Dalton trans. 2018, 47 (32), 11253-11263. DOI: 10.1039/c8dt02436g.

(24) Liu, Y.; Zhang, C.; Liu, H.; Li, Y.; Xu, Z.; Li, L.; Whittaker, A. Controllable synthesis of up-conversion nanoparticles UCNPs@ MIL-PEG for pH-responsive drug delivery and potential up-conversion luminescence/magnetic resonance dual-mode imaging. J. Alloys Compd. 2018, 749, 939-947. DOI: 10.1016/j.jallcom.2018.03.355.

(23) Li, L.; Zhang, C.; Zhang, R.; Xu, Z.; Xu, Z.; Whittaker, A. K. Multifunctional magnetized porous silica covered with poly (2-dimethylaminoethyl methacrylate) for pH controllable drug release and magnetic resonance imaging. ACS Appl. Nano Mater. 2018, 1 (9), 5027-5034. DOI: 10.1021/acsanm.8b01131.

(22) Lawrence, J.; Zhang, C.; Kim, D. S.; Hawker, C.; Whittaker, A. Elucidating the impact of dispersity on the 19F NMR dynamics and MRI performance of fluorinated oligomers. In Abstracts of Papers of the American Chemical Society, 2018; American Chemical Society: Vol. 256.

(21) Han, F. Y.; Whittaker, A. K.; Howdle, S. M.; Naylor, A.; Shabir-Ahmed, A.; Zhang, C.; Smith, M. T. Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics 2018, 10 (4), 264. DOI: 10.3390/pharmaceutics10040264

(20) Fu, C.; Zhang, C.; Peng, H.; Han, F.; Baker, C.; Wu, Y.; Ta, H.; Whittaker, A. K. Enhanced performance of polymeric 19F MRI contrast agents through incorporation of highly water-soluble monomer MSEA. Macromolecules 2018, 51 (15), 5875-5882. DOI: 10.1021/acs.macromol.8b01190.