Ngo Group Publications

2020

Lucia, D., McCombe, P.A., Henderson, R.D., and Ngo, S.T. Disorders of sleep and wakefulness in amyotrophic lateral sclerosis (ALS): a systematic review. 2020. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi: 10.1080/21678421.2020.1844755

Bouscary, A., Quessada, C., Rene, F., Spedding, M., Turner, B.J., Henriques, A., Ngo, S.T., and Loeffler, J-P. Sphingolipid metabolism in the CNS: Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases. 2020. Seminars in Cell and Developmental Biology. doi: 10.1016/j.semcdb.2020.10.008

Iacoangeli, A., Lin, T., Al Khleifat, A., Jones, A.R., Opie-Martin, S., Shatunov, A., Coleman, J.R.I., Sproviero, W., Williams, K.L., Garton, F., Restuadi, R., Henders, A.K., Mather, K.A., Needham, M., Mathers, M., Nicholson, G.A., Rowe, D.B., Henderson, R., McCombe, P.A., Pamphlett, R., Blair, I.P., Schultz, D., Sachdev, P.S., Newhouse, S.J., Fogh, I., Ngo, S.T., Dobson, R.J.B., Wray, N.R., Steyn, F.J. Al-Chalabi, A. Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss with the disease genetics. 2020. Cell Reports. 33(4):108323

Tracey, T.J., Kirk, S.E., Steyn, F.J., and Ngo, S.T. The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis. 2020. Seminars in Cell and Developmental Biology. doi.org/10.1016/j.semcdb.2020.08.012

Steyn, F.J., Li, R., Kirk, S.E., Tefera, T.W., Xie, T.Y., Tracey, T.J., Kelk, D., Wimberger, E., Garton, F.C., Roberts, L., Chapman, S.E., Coombes, J.S., Leevy, W.M., Ferri, A., Valle, C., Rene, F., Loeffler, J-P., McCombe, P.A., Henderson, R.D., and Ngo, S.T. Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. 2020. Brain Communications. 2 (2): fcaa154

Kobayashi, T., Lam, P.Y., Jiang, H., Bednarksa, K., Gloury, R.E., Murigneux, V., Tay, J., Jacquelot, N., Li, R., Tuong, Z.K., Leggatt, G., Gandhi, M.K., Hill, M., Belz, G., Ngo, S., Kallies, A., and Mattarollo, S.R. Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. 2020. Blood. 136 (26): 3004-3017.

Bouscary, A., Quessada, C., Rene, F., Spedding, M., Henriques, A., Ngo, S., and Loeffler, J-P. Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases. 2020. European Journal of Pharmacology. doi.org/10.1016/j.ejphar.2020.173446

Ngo, S.T.*, Restuadi, R.*, McRae, A.F., van Eijk, R.P.A., Garton, F.C., Henderson, R.D., Wray, N.R., McCombe, P.A., and Steyn, F.J. Progression and survival of patients with motor neuron disease relative to their faecal microbiota. 2020. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 21 (7-8): 549-562.

Steyn, F.J., and Ngo, S.T. Prognostic value of weight loss in patients with amyotrophic lateral sclerosis. 2020. Journal of Neurology, Neurosurgery, and Psychiatry. 91 (8): 813.

Scaricamazza, S., Salvatori, I., Giacovazzo, G., Loeffler, J-P., Renè, F., Rosina, M., Quessada, C., Proietti, D., Heil, C., Rossi, S., Battistini, S., Giannini, F., Volpi, N., Steyn, F.J., Ngo, S.T., Ferraro, E., Madaro, L., Coccurello, R., Valle, C., and Ferri, A. Skeletal muscle metabolic reprogramming in ALS-SOD1G93A mice predates disease onset and is a promising therapeutic target. 2020. iScience. 23 (5): 101087.

McGill, R.B., Steyn, F.J., Ngo, S.T., Thorpe, K.A., Heggie, S., Ruitenberg, M.J., Henderson, R.D., McCombe, P.A., and Woodruff, T.M. Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. 2020. Brain Communications. 2 (1): fcaa013.

Nabais, M.F., Lin, T., Benyamin, B., Williams, K.L., Garton, F.C., Vinkhuyzen, A.A.E., Zhang, F., Vallerga, C.L., Restuadi, R., Zwamborn, R.A.J., Hop, P., Robinson, M.R., Gratten, J., Visscher, P.M., Hannon, E., Mill, J., Brown, M.A., Laing, N.G., Mather, K.A., Sachdev, P.S., Ngo, S.T., Steyn, F.J., Wallace, L., Henders, A.K., Needham, M., Veldink, J.H., Mathers, S., Nicholson, G., Rowe, D.B., Henderson, R.D., McCombe, P.A., Pamphlett, R., Yang, J.*, Blair, I.P.,*, McRae, A.F.*, and Wray, N.R*. Significant out-of-sample classification from methylome-wide association study of amyotrophic lateral sclerosis. 2020. npj Genomic Medicine. 5: 10

2019

McCombe, P.A., Henderson, R.D., Lee A, Woodruff, T., Lee, J., Restuadi, R., McRae, A., Wray, N.R., Ngo, S.T., and Steyn F.J. Gut microbiota in ALS: possible role in pathogenesis? 2019. Expert Review of Neurotherapeutics. 19 (9): 785-805.

Ngo, S.T.,* van Eijk, R.P.A.,* Chachay, V., van den Berg, L.H., McCombe, P.A., Henderson, R.D., and Steyn, F.J. Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis. 2019. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20 (7-8): 497-505.

Kirk, S.E., Tracey, T.J., Steyn, F.J., and Ngo, S.T. Biomarkers of metabolism in amyotrophic lateral sclerosis. 2019. Frontiers in Neurology. 10: 191.

McCombe, P.A., Ngo, S.T., Guo, C.C., Fazlollahi, A., Bollmann, S., Wang, L., Hu, X., Barth, M., Salvado, O., Davis, M., Ceslis, A., Robinson, G.A., Henderson, R.D., and Steyn, F.J. An ALS patient with a novel TBK1 mutation, widespread brain involvement, behaviour changes, and metabolic dysfunction. 2019. Journal of Neurology, Neurosurgery, and Psychiatry. 90 (8): 952-954.

2018

Steyn, F.J., Ioannides, Z.A., van Eijk, RPA., Heggie, S., Thorpe, K.A., Ceslis, A., Heshmat, S., Henders, A.K., Wray, N.R., van den Berg, L.H., Henderson, R.D., McCombe, P.A., and Ngo, S.T. Hypermetabolism in ALS is associated with greater functional decline and shorter survival. Journal of Neurology, Neurosurgery, and Psychiatry. 2018. 89 (10): 1016-1023.

Tracey, T.J., Steyn, F.J., Wolvetang, E.J., and Ngo, S.T. Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience. 2018. 11: 10.

Steyn, F.J., Ngo, S.T., Chen, V., Brimijoin, S., Freeman, W., Xie, T.Y., Ghadami, M., Low, M., and Stout, M.B. 17α-estradiol acts through hypothalamic proopiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell. 2018. 17 (1): e12703.

2017

Benyamin, B., He, J., Zhao, Q., Gratton, J., Garton, F., Leo, P., Liu, Z., Mangelsdorf, M., Al-Chalabi, A., Anderson, L., Butler, T., Chen, L., Chen, X-D., Cremin, K., Deng, H-W., Devine, M., Edson, J., Fifita, J., Furlong, S., Han, Y-Y., Harris, J., Henders, A., Jeffree, R., Jin, Z-B., Li, Z., Li, T., Li, M., Lin, Y., Liu, X., Marshall, M., McCann, E., Mowry, B., Ngo, S.T., Pamphlett, R., Ran, S., Reutens, D., Rowe, D.B., Sachdev, P., Shah, S., Song, S., Tan, L-J., Tang, L., van den Berg, L., van Rheenen, W., Veldink, J., Wallace, R., Wheeler, L., Williams, K., Wu, J., Wu, X., Yang, J., Yue, W., Zhang, Z-H., Zhang, D., Blair, I., Henderson, R., McCombe, P., Noakes, P., Visscher, P.M., Xu, H., Bartlett, P., Brown, M., Wray, N.R., Fan, D. 2017. Cross-ethnic meta-analyses identify a new risk locus for amyotrophic lateral sclerosis. Nature Communications.

A2. Ngo, S.T., Mi, J.D., Henderson, R.D., McCombe, P.A., and Steyn, F.J. 2017. Exploring Targets and Therapies for Amyotrophic Lateral Sclerosis: Current Insights on Dietary Interventions. Degenerative Neurological and Neuromuscular Disease.

A3. Ioannides, Z.A., Steyn, F.J., Henderson, R.D., McCombe, P.A., and Ngo, S.T. 2017. Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass. Cogent Medicine. 4: 1343000.

A4. Ioannides, Z.A., Steyn, F.J., Henderson, R.D., McCombe, P.A.*, and Ngo, S.T.* 2017. Anthropometric measures are not accurate predictors of fat mass in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 10.1080/21678421.2017.1317811

Russell, A.P., Ghobrial, L., Ngo, S.T., Yerbury, J., Zacharewicz, E., Chung, R., and Lamon, S. Dysregulation of miRNA biogenesis machinery and miRNA/RNA ratio in skeletal muscle of ALS mice. Muscle Nerve. 2017. 57 (5): 838-847.

Steyn, F.J., and Ngo, S.T. Endocrine rhythms of growth hormone release: insights from animal studies. Best Practice and Research: Clinical Endocrinology and Metabolism. 2017. 31 (6):521-533.

2016

Carrasco-Pozo, C., Tan, K-N., Reyes-Fairias, M., de la Jara, N., Ngo, S.T., Garcia, D., Llanos, P., and Borges, K. 2016. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies. Redox Biology. 26 (9): 229-243.

Tefera, T., Wong, Y., Ngo, S.T., Thomas, N., McDonald, T., and Borges, K. 2016. Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis. Plos One. 11 (8): e0161816.

Fogarty, M.J., Klenowski, P.M., Lee, J.D., Drieberg-Thompson, J.R., Bartlett, S.E., Ngo, S.T., Hilliard, M.A., Bellingham, M.C., and Noakes, P.G. 2016. Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports. 6:37968.

Li, R., Steyn, F.J., Stout, M.B., Lee, K., Cully, T.R., Calderon, J.C., and Ngo, S.T. 2016.
Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles.
The Journal of Physiology. doi: 10.1113/JP272988.
URL: Li et al, 2016

Ioannides, Z.A. Ngo, S.T., Henderson, R.D., McCombe, P.A., and Steyn, F.J. 2016.
Altered metabolic homeostasis in Amyotrophic Lateral Sclerosis: Mechanisms of energy imbalance and contribution to disease progression.
Neurodegenerative Diseases. 16 (5-6):382-397.
URL: Ioannides et al, 2016

2015

Ngo, S.T., and Steyn, F.J. 2015.
The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of Amyotrophic Lateral Sclerosis.
Cell Regen (Lond). 4 (1): 5.
URL: Ngo and Steyn 2015

Ngo, S.T., Steyn, F.J., Huang, L., Mantovani, S., Pfluger, C., Woodruff, T.M., O'Sullivan, J.D., Henderson, R.D., and McCombe, P.A. 2015.
Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis (ALS).
Journal of the Neurological Sciences. 357 (1-2): 22-27.
URL: Ngo et al, 2015

Palamiuc, L., Schlagowski, A., Ngo, S.T., Vernay, A., Grosch, S., Henriques, A., Boutillier, A-L., Zoll, J., Echaniz-Laguna, A., Loeffler, J-P., and René, F. 2015.
A metabolic switch towards lipid use in glycolytic muscle is an early pathologic event in a mouse model of Amyotrophic Lateral Sclerosis.
EMBO Molecular Medicine. 7: 524-46.
URL: Palamuic et al, 2015

2014

Ngo, S.T., Steyn, F.J., and McCombe, P.A. 2014.
Gender differences in autoimmune disease.
Frontiers in Neuroendocrinology. 35 (3): 347-369.
URL: Ngo et al, 2014

Ngo, S.T. Steyn, F.J., and McCombe, P.A. 2014.
Body mass index and dietary intervention: implications for prognosis of Amyotrophic Lateral Sclerosis.
Journal of the Neurological Sciences. 340 (1-2): 5-12.
URL: Ngo et al, 2014

2013

2012

Ngo, S.T., Cole, R.N., Sunn, N., Phillips, W.D., and Noakes, P.G. 2012. Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering via muscle specific kinase phosphorylation. Journal of Cell Science. 125 (Pt 6): 1531-1543.

Steyn, F.J., Ngo, S.T., Lee, J.D., Leong, J.W., Buckley, A.J., Veldhuis, J.D., McCombe, P.A., Chen, C., and Bellingham, M.C. 2012.
Impairments to the GH-IGF1 axis in hSOD1G93A mice give insight into possible mechanisms of GH dysregulation in patients with Amyotrophic Lateral Sclerosis.
Endocrinology. 153 (8): 3735-3746.
URL: Steyn et al, 2012

Ngo, S.T., Baumann, F., Ridall, P.G., Pettitt, A.N., Henderson, R.D., Bellingham, M.C., and McCombe, P.A. 2012.
The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1G93A mice.
Clinical Neurophysiology. 123 (10): 2080-91.

URL: Ngo et al, 2012