Madushani specialises in the design and fabrication of nanoarchitectonic systems and extracellular vesicle (EV)-based biointerfaces for cancer biosensing, diagnostics, and translational nanomedicine.
Madushani Dahanayake is a Higher Degree by Research (HDR) scholar whose research focuses on the design and fabrication of novel nanostructures and nano-diagnostic technologies for cancer theranostics. Her work integrates nanotechnology, nanobiotechnology, and materials science to develop next-generation platforms for the detection and monitoring of cancer-associated biomarkers. Currently, she is investigating alloy nanozymes as catalytic signal amplification materials for point-of-care extracellular vesicle (EV) biosensing, with a particular focus on ovarian cancer diagnostics. Her broader research interests include nanoarchitectonics, EV technologies, nanozyme-enabled biosensing, nanomedicine, and the development of rapid, accessible diagnostic tools for precision healthcare.
Key Publications
M. Dahanayake, M. S. A. Hossain, C.-H. Liu, C. Salomon, Y. Yamauchi, and M. K. Masud, “ How is Nanoarchitectonics Shaping Extracellular Vesicle Research?.” Advanced Healthcare Materials (2026): e71611. https://doi.org/10.1002/adhm.71611
Guanzon, D., Sankar, R., Lodha, P., Purushothaman, R., Huang, S., Jayabalan, N., Dahanayake, M., Ahmed, E., Han, P., Masud, M. K., Yamauchi, Y., & Salomon, C. (2026). Circulating extracellular vesicle DNA (EV-DNA) and cell-free DNA in ovarian cancer: pathological relevance and diagnostic applications. Extracellular vesicles and circulating nucleic acids, 7(1), 114–145. https://doi.org/10.20517/evcna.2025.120
Madushani H. Dahanayake, Sandya S. Athukorala, A. C. A. Jayasundera; Recent breakthroughs in nanostructured antiviral coating and filtration materials: a brief review. RSC Adv. 2022; 12 (26): 16369–16385. https://doi.org/10.1039/d2ra01567f
Dahanayake, M. H., & Jayasundera, A. C. (2021). Nano-based drug delivery optimization for tuberculosis treatment: a review. Journal of microbiological methods, 181, 106127. https://doi.org/10.1016/j.mimet.2020.106127
Dahanayake, M. H., Gamage, C. D., Sirimuthu, N. M. S., & Jayasundera, A. C. A. (2020). A novel approach for qualitative biosensing of anti-leptospiral IgG antibodies in human sera using functionalised silver nanoparticles. Journal of the National Science Foundation of Sri Lanka, 48(4), 437-447. https://doi.org/10.4038/jnsfsr.v48i4.9642