Multi-disciplinary approaches, combining advanced biomaterials, microfluidics and laboratory automation, to address complex stem cell biology problems

Combinatorial high throughput biomaterial screening and assessment for tissue engineering and regenerative medicine

Steffen Cosson obtained his M.Sc. degree in Bioengineering and Biotechnology at the École Polytechnique Fédérale de Lausanne (EPFL), in Switzerland, in 2008, as part of the first class ever graduating from EPFL’s School of Life Sciences. He received his PhD degree from the Institute of Bioengineering at EPFL under the supervision of Professor Matthias P. Lutolf, in 2012. During his PhD, he designed and validated novel hydrogel microfluidic devices for (i) gradient micro-patterning on hydrogel biomimetic substrates and (ii) delivery of soluble factor gradient to cell aggregate microarrays, demonstrating spatial control over stem cell differentiation. Following a short postdoctoral research transition period in the same laboratory, in which he devised a versatile multi-layer microfluidic device rapid prototyping technique relying on xurography and laser micromachining, he joined as a post doctoral fellow in a joint appointment between the AIBN (UQ) and Manufacturing (CSIRO) under the OCE Science Leader grant to Professor Justin J. Cooper-White. Since then he has been working on combinatorial high throughput biomaterial synthesis, screening and assessment for tissue engineering and regenerative medicine.

Funding

Canton of Vaud Scholarship for independents, 14’000CHF per annum, 2006-2008

Key Publications

  1. Rapid combinatorial libraries of mikto-arm star polymer synthesis via aqueous one-pot RAFT, S. Cosson, M. Danial, J. Rosselgong Saint-Amans and J. J. Cooper-White; World Biomaterials Congress, 2016, Montreal, Canada
  2. Concise review: Tailoring bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine, S. Cosson, E. Otte, H. Hezaveh and J.J. Cooper-White, Stem Cells Translational Medicine, 2015
  3. Ultra-rapid prototyping of flexible, multi-layered microfluidic devices via razor writing, S. Cosson, L.G. Aeberli, N. Brandenberg and M.P. Lutolf, Lab on a Chip, 2015
  4. Spatiotemporal control of stem cell fate by hydrogel microfluidics, S. Cosson and M.P. Lutolf, Scientific Reports, 2014