Industrial synthetic engineering in Sacharomyces cerevisiae: from gene expression regulation to terpenoid production

Bingyin Peng uses the budding yeast Saccharomyces cerevisiae to develop microbial cell factories for the production of natural flavours, fragrances, and pharmaceuticals. He is  interested in understanding genetic responses of yeast under industry-relevent conditions and engineering genetic regulatory networks to optimize heterogeneous gene expression for yeast cell factory development. Currently, he is 1) using metabolic engineering methods to develop yeast cell factories for the production of terpenoids, i.e., trans-nerolidol, linalool, and limonene; 2) interpreting the perturbation of carbon sources on gene expression; and 3) engineeing molecular regulatory networks to optimize yeast performance in industrial processes. 

Mr Peng completed his Bachelor degree in biochemistry and molecular biology at Liaoning University (Shenyang City, China) in 2008 and his Master degree in microbiology at Shandong University (Jinan City, China) in 2011. He then worked as a research engineer in Ngee Ann Polytechnic, Singapore. In 2013, he enrolled into the PhD program at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at the University of Queensland. 

Key Publications

  1. Bingyin Peng, Manuel R. Plan, Alexander Carpenter, Lars K. Nielsen, Claudia E. Vickers. Coupling gene regulatory patterns to bioprocess conditions to optimize synthetic metabolic modules for improved sesquiterpene production in yeast. Biotechnology for Biofuels, 2017, 10:43. DOI: 10.1186/s13068-017-0728-x 
  2. Bingyin Peng, Manuel R. Plan, Panagiotis Chrysanthopoulos, Mark P. Hodson, Lars K. Nielsen, Claudia E. Vickers. A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiaeMetabolic Engineering, 2017, 39: 209–219. DOI: 10.1016/j.ymben.2016.12.003
  3. Bingyin Peng, Thomas C. Williams, Matthew Henry, Lars K. Nielsen and Claudia E. Vickers. Controlling heterologous gene expression in yeast cell factories on different carbon substrates and across the diauxic shift: A comparison of yeast promoter activities. Microbial Cell Factories, 2015, 14:91. DOI: 10.1186/s12934-015-0278-5 
  4. Bingyin Peng, Shuangcheng Huang, Tingting Liu, Anli Geng. Bacterial xylose isomerases from the mammal gut Bacteroidetes cluster function in Saccharomyces cerevisiae for effective xylose fermentation. Microbial Cell Factories, 2015, 14:70. DOI: 10.1186/s12934-015-0253-1 
  5. Bingyin Peng1, Yu Shen1, Xiaowei Li, Xiao Chen, Jin Hou, Xiaoming Bao. Improvement of xylose fermentation in respiratory-deficient xylose-fermenting Saccharomyces cerevisiaeMetabolic Engineering, 2012, 14(1):9-18. DOI: 10.1016/j.ymben.2011.12.001