The impact of silica nanocapsules' stiffness on their cellular interaction and biodistribution.

​Mr. Yue Hui is interested in exploring the impact of nanocapsules' stiffness on their biological behaviors such as cellular interactions and biodistribution, as it is of importance for the future design of nanocarriers for targeted drug delivery. To do this, he synthesized oil-core silica-shell nanocapsules having controllable stiffness based on the technology developed in Middelberg lab and investigated the cellular interactions of these capsules by administrating them to different cell types. 

Key Publications

Y. Hui, D. Wibowo, C.-X. Zhao, "Insights into the Role of Biomineralizing Peptide Surfactants on Making Nanoemulsion-Templated Silica Nanocapsules" Langmuir, 2016, 32, 822.

D. Wibowo, Y. Hui, A. P. J. Middelberg, C.-X. Zhao, "Interfacial Engineering for Silica Nanocapsules" Advances in Colloid and Interface Science, 2016, 236, 83.

C.-X. Zhao, D. Chen, Y. Hui, D. A. Weitz, A. P. J. Middelberg, "Stable Ultrathin-Shell Double Emulsions for Controlled Release" ChemPhysChem, 2016, 17, 1553.

C.-X. Zhao, D. Chen, Y. Hui, D. A. Weitz, A. P. J. Middelberg, "Controlled Generation of Ultrathin-Shell Double Emulsions and Studies on Their Stability" ChemPhysChem, 2017, 18, 1393.