Microfluidic platform for the development of polymeric nanocarriers for cancer drug delivery 

Ms Thejus Baby's research is focussed on the development of a microfluidic platform technology for the synthesis of biodegradable polymeric nanocarriers. In her project, she investigated the effect of different design parameters on the throughput capacities of 2D microfluidic devices and developed 3D microfluidic devices for the synthesis of high drug loading polymeric nanocarriers for colon cancer drug delivery. 

Thejus obtained B. Tech in Biotechnology and M. Tech in Nanomedicine from India. She worked as Junior research fellow in NCCS, India before joining for PhD. 

Key Publications

  1. Baby, Thejus., Liu, Yun., Middelberg, Anton P.J., Zhao, Chun-Xia. (2017)  Fundamental studies on throughput capacities of hydrodynamic flow-focusing microfluidics for producing monodisperse polymer nanoparticles.  Chemical Engineering Science, 169, 128-139.
  2. Ran, Rui., Sun, Qi., Baby, Thejus., Wibowo, David., Middelberg, Anton P. J., Zhao, Chun-Xia. (2017) Multiphase microfluidic synthesis of micro- and nanostructures for pharmaceutical applications. Chemical Engineering Science, 169, 78-96.
  3. Rejinold, N. Sanoj., Baby, Thejus., Chennazhi, K. P., Jayakumar, R. (2015) Multi Drug Loaded Thermo-Responsive Fibrinogen-graft-Poly (N-vinyl Caprolactam) nanogels for Breast Cancer Drug Delivery. Journal of Biomedical Nanotechnology, 11, 392-402. 
  4. Rejinold, N. Sanoj., Baby, Thejus., Chennazhi, K. P., Jayakumar, R. (2014) Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy. Colloids and surfaces B: Biointerfaces, 114, 209-217.
  5. Rejinold, N. Sanoj., Baby, Thejus., Nair, ShantiKumar V., Jayakumar, R. (2013) Paclitaxel loaded fibrinogen coated CdTe/ ZnTe core shell nanoparticles for targeted imaging and drug delivery to breast cancer cells. Journal of Biomedical Nanotechnology, 9, 1657-1671.