Investigating the role of the complement system in cancer

Dr. Manthey has over 10 years’ experience in the fields of pharmacology, vascular biology and immunology.  She was the first person to demonstrate a role for complement C5a in a mouse model of atherosclerosis, using an antagonist developed at UQ.  In the last 4 years, working with Dr Barbara Rolfe, she has been involved with investigating the role of complement in cancer, and is a contributor on the patent arising from this work.

While working in the field of vascular biology she was also involved in testing novel imaging techniques for visualisation of atherosclerosis in mice and elucidating the role of chemokine receptor 6 (CCR6) in atherosclerosis.  She has expertise in numerous animal models of inflammatory disease such as endotoxic shock, atherosclerosis, inflammatory bowel disease, melanoma and breast cancer as well as a broad range of biological techniques, in particular, flow cytometry and immunohistochemistry.​

Collaborations

International collaborations including with Prof Alma Zernecke (Germany), Dr. Ruben Pio (Spain) Dr Anita Thomas and Prof Peter Monk (UK).  Local collaborations include Assoc Prof Trent Woodruff (UQ), Assoc Prof Andrew Barbour (School of Medicine), Drs Martina Jones and Kris Thurecht (AIBN).​

Key Publications

Nabizadeh JA, Manthey HD, Steyn FJ, Chen W, Widiapradja A, Md Akhir FN, Boyle GM, Taylor SM, Woodruff TM, Rolfe BE. The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. J Immunol. 2016 Jun 1;196(11):4783-92

Manthey HD, Cochain C, Barnsteiner S, Karshovska E, Pelisek J, Koch M, Chaudhari SM, Busch M, Eckstein HH, Weber C, Koenen RR, Zernecke A. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thromb Haemost. 2013 Dec;110(6):1267-77

Michalska M., Machtoub L., Manthey H.D.,  Bauer E., Herold V., Krohne G., Lykowsky G., Hildenbrand M., Kampf T., Jakob P., Zernecke A., Bauer W. R. Visualisation of vascular inflammation in the atherosclerotic mouse by USPIO VCAM-1-specific nanoparticles. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2350-7

Manthey H.D., Zernecke A. Dendritic cells in atherosclerosis: functions in immune regulation and beyond. Thromb Haemost. 2011 Nov;106(5):772-8

Manthey H.D., Thomas A.C., Shiels I.A., Zernecke A., Woodruff T.M., Rolfe B., Taylor S.M. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 2011 Jul;25(7):2447-55