Jong Huat’s research specialised in the impact of astrocyte-mediated neuroinflammation on Alzheimer’s disease.

Jong Huat’s research is focused on the molecular mechanism underlying astrocyte-mediated neuro-inflammation in Alzheimer’s disease as well as during ageing. In his study, he will use both in vitro and in vivo approaches to investigate neuro-inflammatory related pathways.

Jong Huat has obtained his BSc (Hons) in Biological Sciences from the University Malaysia Terengganu, Malaysia. In the year 2013, he was awarded a doctoral research fellowship from University Sains Malaysia to pursue his PhD degree under the mentorship of Prof. Dr Hasnan Jaafar and Prof. Dr Jafri Malin Abdullah. Jong Huat’s PhD research focused on the role of essential microRNA in growth factor-mediated neural differentiation of mesenchymal stem cells and was successfully completed in the year 2017. Jong Huat is passionate about stem cell research and interested in exploring the potential application of stem cell in treating neurodegenerative diseases.  In January 2018, Jong Huat joined the Neurula Lab as associate research fellow and applied his skills to investigate the impact of astrocyte-mediated neuro-inflammation on Alzheimer’s disease.


Key Publications

Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat & Rodrigo Medeiros. (2018). Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease. Journal of Neuroinflammation 15:276.

Soumya Pati, Sangu Muthuraju, Raisah Ab. Hadi, Tee Jong Huat, Shailja Singh, Mirjana Maletic-Savatic, Jafri Malin Abdullah & Hasnan Jaafar. (2016). Neurogenic plasticity of mesenchymal stem cells, an alluring cellular replacement for traumatic brain injury. Current Stem Cell Research & Therapy 11(2): 149-157.

Tee Jong Huat, Amir Ali Khan, Jafri Malin Abdullah, Fauziah Mohamad Idris & Hasnan Jaafar. (2015). MicoRNA Expression Profile of Neural Progenitor-like Cells Derived from Rat Bone Marrow Mesenchymal Stem Cells under the Influence of IGF-1, bFGF and EGF. International Journal of Molecular Sciences 16: 9693-9718.

Sim Sze Kiat, Tan Yew Chin, Tee Jong Huat, Abdul Aziz Yusoff & Jafri Malin Abdullah. (2015). Paclitaxel inhibits expression of neuronal nitric oxide synthase and prevents mitochondrial dysfunction in spinal ventral horn in rats after C7 spinal root avulsion. Turkish Neurosurgery25(4):617-624.

Tee Jong Huat, Amir Ali Khan, Soumya Pati, Zulkifli Mustafa, Jafri Malin Abdullah & Hasnan Jaafar. (2014). Insulin-like growth factor 1 enhances in vitro transdifferentiation of mesenchymal stem cells to neural progenitor cells. BMC Neuroscience 15:91.