Dr Mahfuz Chowdhury specialises in developing and optimising biological processes using multidisciplinary approaches: stem cell engineering and reprogramming, microfluidics, biomaterials and computational biology.

Fine tuning of cellular microenvironment (soluble and physical) is crucial to obtain robust output from various cell processes, like stem cell differentiation to a specific lineage. I have demonstrated that scaling down of stem cell culture (by using microfluidics) can activate their autocrine signalling and maintain their phenotype more robustly than conventional cultures. In addition, by developing a mathematical model of the culture system, I determined the dimensional requirement of the culture system to activate autocrine signalling.  In another project, I developed pericytes and endothelial cell co-culture on hydrogels which enhanced organ-specific behaviour of endothelial cells, which in turn modulated cancer cell adhesion in an organ-specific manner. In a recent project, I have fabricated and optimised hydrogel systems to improve fibroblast reprogramming into Pluripotent Stem Cells (iPSCs).

Dr Mahfuz Chowdhury completed his MSc in Korea Advanced Institute of Science and Technology and his PhD with The University of Tokyo. He was awarded Korea Research Foundation and Japan Ministry of Education, Culture, Science and Technology Scholarships for his MSc and PhD research.

His research focuses on developing advanced cell culture systems for optimising cellular processes or drug screening. Currently, he is investigating the impact of ageing on angiogenesis processes by utilising hydrogels, microfluidic and 3D printing.