Investigating the role of the complement system in cancer

Dr Manthey has over 10 years’ experience in the fields of pharmacology, vascular biology and immunology.  She was the first person to demonstrate a role for complement C5a in a mouse model of atherosclerosis, using an antagonist developed at UQ.  In the last 4 years, working with Dr Barbara Rolfe, she has been involved with investigating the role of complement in cancer, and is a contributor on the patent arising from this work.

While working in the field of vascular biology she was also involved in testing novel imaging techniques for visualisation of atherosclerosis in mice and elucidating the role of chemokine receptor 6 (CCR6) in atherosclerosis.  She has expertise in numerous animal models of inflammatory disease such as endotoxic shock, atherosclerosis, inflammatory bowel disease, melanoma and breast cancer as well as a broad range of biological techniques, in particular, flow cytometry and immunohistochemistry.​

Collaborations

International collaborations including with Prof Alma Zernecke (Germany), Dr. Ruben Pio (Spain) Dr Anita Thomas and Prof Peter Monk (UK).  Local collaborations include Assoc Prof Trent Woodruff (UQ), Assoc Prof Andrew Barbour (School of Medicine), Drs Martina Jones and Kris Thurecht (AIBN).​

Publications

  1. Vorlova, SandraKoch, MiriamManthey, Helga D.Cochain, ClementBusch, MartinChaudhari, Sweena M.Stegner, DavidYepes, ManuelLorenz, KristinaNolte, Marc W.Nieswandt, Bernhard and Zernecke, Alma (2017)Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in miceThrombosis and Haemostasis117 1: 176-187. doi:10.1160/TH16-06-0466
  2. Nabizadeh, Jamileh A.Manthey, Helga D.Steyn, Frederik J.Chen, WeiyuWidiapradja, AlexanderAkhir, Fazrena N. MdBoyle, Glen M.Taylor, Stephen M.Woodruff, Trent M. and Rolfe, Barbara E. (2016)The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responsesJournal of Immunology196 11: 4783-4792. doi:10.4049/jimmunol.1600210
  3. Chaudhari, Sweena M.Sluimer, Judith C.Koch, MiriamTheelen, Thomas L.Manthey, Helga D.Busch, MartinCaballero-Franco, CeliaVogel, FrederickCochain, ClementPelisek, JaroslavDaemen, Mat J.Lutz, Manfred B.Görlach, AgnesKissler, StephanHermanns, Heike M. and Zernecke, Alma (2015)Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in MiceArteriosclerosis, Thrombosis, and Vascular Biology35 11: 2316-2325. doi:10.1161/ATVBAHA.115.306171
  4. Manthey, H. D.Cochain, C.Barnsteiner, S.Karshovska, E.Pelisek, J.Koch, M.Chaudhari, S. M.Busch, M.Eckstein, H. H.Weber, C.Koenen, R. R. and Zernecke, A. (2013)CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in miceThrombosis and Haemostasis110 6: 1267-1277. doi:10.1160/TH13-01-0017
  5. Matsumoto, AyaManthey, Helga D.Marsh, Susan A.Fassett, Robert G.de Haan, Judy B.Rolfe, Barbara E. and Coombes, Jeff S. (2013)Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE−/− miceInternational Journal of Cardiology167 4: 1282-1288. doi:10.1016/j.ijcard.2012.03.172
  6. Michalska, MartaMachtoub, LinaManthey, Helga D.Bauer, ElisabethHerold, VolkerKrohne, GeorgLykowsky, GunthardHildenbrand, MarkusKampf, ThomasJakob, PeterZernecke, Almaand Bauer, Wolfgang R. (2012)Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticlesArteriosclerosis Thrombosis and Vascular Biology32 10: 2350-2357. doi:10.1161/ATVBAHA.112.255224
  7. Doering, YvonneManthey, Helga D.Drechsler, MaikLievens, DirkMegens, Remco T. A.Soehnlein, OliverBusch, MartinManca, MarcoKoenen, Rory R.Pelisek, JaroslavDaemen, Mat J.Lutgens, EstherZenke, MartinBinder, Christoph J.Weber, Christian and Zernecke, Alma (2012)Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosisCirculation125 13: 1673-1683. doi:10.1161/CIRCULATIONAHA.111.046755
  8. Manthey, Helga D. and Zernecke, Alma (2011)Dendritic cells in atherosclerosis: functions in immune regulation and beyondThrombosis and Haemostasis106 5: 772-778. doi:10.1160/TH11-05-0296
  9. Manthey, Helga D.Thomas, Anita C.Shiels, Ian A.Zernecke, AlmaWoodruff, Trent M.Rolfe, Barbara and Taylor, Stephen M. (2011)Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) miceFASEB Journal25 7: 2447-2455. doi:10.1096/fj.10-174284
  10. Manthey, Helga D.Woodruff, Trent M.Taylor, Stephen M. and Monk, Peter N. (2009)Complement component 5a (C5a)International Journal of Biochemistry and Cell Biology41 11: 2114-2117. doi:10.1016/j.biocel.2009.04.005
  11. Woodruff, T. M.Pollitt, S.Proctor, L. M.Stocks, S. Z.Manthey, H. D.Williams, H. M.Mahadevan, I. B.Shiels, I. A. and Taylor, S. M. (2005)Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel diseaseJournal of Pharmacology And Experimental Therapeutics314 2: 811-817. doi:10.1124/jpet.105.086835
  12. Wu, M. C. L.Moore, T. A.Manthey, H. D.Taylor, S. M. and Woodruff, T. M. (2010).The role of complement anaphylatoxin receptors in mesenteric ischemia/reperfusion-induced injury. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2270-2270). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.216
  13. Denny, KerinaWoodruff, TrentPavlovski, DaleManthey, HelgaPaul ColditzRichard Finnell and Stephen Taylor (2008).The role of C5a in reproductive impairment in the mouse and human. In: Robert Rieben, XXII International Complement Workshop. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.164
  14. Manthey, HelgaThomas, AnitaTaylor, StephenWoodruff, TrentMoore, TysonShiels, Ian and Rolfe, Barbara (2008).Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. In: ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4151-4151). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.167
  15. Moore, TysonWoodruff, TrentManthey, HelgaMonk, PeterTaylor, Stephen and Shiels, Ian (2008).Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. In: Robert Rieben, ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September-2 October 2008. doi:10.1016/j.molimm.2008.08.165
  16. Manthey, H.Taylor, S.Shiels, I. and Rolfe, B. (2007).Does C5a have a role in the pathophysiology of atherosclerosis?. In: W.-C. Song and X.-M. Gao, Molecular Immunology: Proceedings XXI International Complement Workshop. XXI International Complement Workshop, Beijing, China, (213-213). 22-26 October 2006. doi:10.1016/j.molimm.2006.07.154
  17. Helga Manthey (2010).Defining the role of C5a in atherosclerosis PhD Thesis, School of Biomedical Sciences, The University of Queensland.