Advanced silica-based nanomaterials for vaccine delivery

​Vaccination remains one of the most effective way to protect human bodies from infectious diseases. Since most highly purified antigenic components are poorly immunogenic, adjuvants are usually required to reproducibly boost antigen presentation and increases the level and duration of the immunity. Due to the lack of Th1 immunity and safety concern raised by using FDA-approved Alum, development of new vaccine adjuvants has entered a golden age of research. Among all the reported materials regarded as possbile adjuvants candidates, mesoporous silica-based nanomaterials (MSNs) have shown great potential in clinical trials for biomedicine in drug delivery, due to the good biocompatibility, monodispersity and tunable structure. Thus, to develp advanced mesoporous silia-based vaccine adjuvants is promising in  efficient and effective vaccination.

Yang Yang achieved his bachelor and master degree from China University of Petroleum (East China). His major was chemical engineering. He is now focusing on material synthesis and new vaccine adjuvants development.

Key Publications

  1. Yang Y, Xu Y, Han B, et al. Effects of synthetic conditions on the textural structure of pseudo-boehmite[J]. Journal of colloid and interface science, 2016, 469: 1-7.
  2. Han B, Yang Y, Xu Y, et al. A review of the direct oxidation of methane to methanol[J]. Chinese Journal of Catalysis, 2016, 37(8): 1206-1215.
  3. Xu B, Yang Y, Xu Y, et al. Synthesis and characterization of mesoporous Si-modified alumina with high thermal stability[J]. Microporous and Mesoporous Materials, 2017, 238: 84-89.
  4. Zhang J, Kong Y, Yang Y, et al. Fast Capture of Fluoride by Anion-Exchange Zirconium–Graphene Hybrid Adsorbent[J]. Langmuir, 2019. Theivendran S, Zhang J, Tang C, et al. Synthesis of biphenyl bridged dendritic mesoporous organosilica with extremely high adsorption of pyrene[J]. Journal of Materials Chemistry A, 2019, 7(19): 12029-12037.