Genome-scale reconstruction and metabolic modelling of plants and algae

Dr Cristiana G.O Dal'Molin is a Bioengineer, Lecturer and member of the Chemical and Biological Engineering Program of the School of Chemical Engineering at the University of Queensland. She is also project leader at the Australian Institute for Bioengineering and Nanotechnology. Dr Dal'Molin is internationally and nationally recognised for her pioneer contributions to the areas of genome-scale reconstruction and metabolic modelling of plants and algae. Dr Dal'Molin is the developer and creator of open source metabolic models (AraGEM, C4GEM and AlgaGEM) used by industry and scientific community to investigate metabolism of plant and algae.

Her expertises are metabolic engineering, genome-scale metabolic reconstruction, multi-tissue modelling, fluxomics, pathway analysis of complex organisms and poor characterized microbiome. Dr. Dal'Molin research integrates high-throughput data sets generated by modern omics technologies with metabolic network reconstructions to study the complexity of biological systems.

Key Publications

  1. Dal'Molin, Cristiana G. O. and Nielsen, Lars K. (2016).Algae genome-scale reconstruction, modelling and applications. In Michael A. Borowitzka, John Beardall and John A. Raven (Ed.), The Physiology of Microalgae (pp. 591-598)Switzerland: Springer International Publishing. doi:10.1007/978-3-319-24945-2_22
  2. Dal'Molin, Cristiana G. O.Quek, Lake-EePalfreyman, Robin W.and Nielsen, Lars K. (2014).Plant genome-scale modeling and implementation. In DieuaideNoubhani, M and Alonso, AP (Ed.), Plant metabolic flux analysis: methods and protocols (pp. 317-332) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-688-7_19
  3. Gomes de Oliveira Dal'Molin, Cristiana, Quek, Lake-EeSaa, Pedro A.Palfreyman, Robin and Nielsen, Lars Keld (2018)From reconstruction to C4 metabolic engineering: a case study for overproduction of polyhydroxybutyrate in bioenergy grassesPlant Science273 50-60. doi:10.1016/j.plantsci.2018.03.027
  4. Gomes de Oliveira Dal'Molin, Cristiana and Nielsen, Lars Keld(2017)Plant genome-scale reconstruction: from single cell to multi-tissue modelling and omics analysesCurrent Opinion in Biotechnology49 42-48. doi:10.1016/j.copbio.2017.07.009
  5. Lim, David K. Y.Schuhmann, HolgerThomas-Hall, Skye R.Chan, Kenneth C. K.Wass, Taylor J.Aguilera, FelipeAdarme-Vega, T. Catalina, Dal'Molin, Cristiana G. O.Thorpe, Glen J.Batley, JacquelineEdwards, David and Schenk, Peer M. (2017)RNA-Seq and metabolic flux analysis of Tetraselmis sp. M8 during nitrogen starvation reveals a two-stage lipid accumulation mechanismBioresource Technology244 Pt 2: 1281-1293. doi:10.1016/j.biortech.2017.06.003
  6. de Oliveira Dal'Molin, Cristiana GomesOrellana, CamilaGebbie, LeighSteen, JenniferHodson, MarkPlan, ManuelChrysanthopoulos, PanagiotisMacqualter, RichardPalfreyman, Robin W. and Nielsen, Lars K. (2016)Metabolic reconstruction of Setaria italica: a systems biology approach for integrating tissue-specific omics and pathway analysis of bioenergy grassesFrontiers in Plant Science7 1138: 1-18. doi:10.3389/fpls.2016.01138
  7. Ormerod, Kate L.Wood, David L. A.Lachner, NancyGellatly, Shaan L.Daly, Joshua N.Parsons, Jeremy D.Dal’Molin, Cristiana G. O.Palfreyman, Robin W.Nielsen, Lars K.Cooper, Matthew A.Morrison, MarkHansbro, Philip M. and Hugenholtz, Philip (2016)Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animalsMicrobiome4 36.1-36.17. doi:10.1186/s40168-016-0181-2
  8. de Oliveira Dal'molin, Cristiana GomesQuek, Lake-EeSaa, Pedro A. and Nielsen, Lars K. (2015)A multi-tissue genome-scale metabolic modelling framework for the analysis of whole plant systemsFrontiers in Plant Science6 JAN: 4.1-4.12. doi:10.3389/fpls.2015.00004
  9. Dal'Molin, Cristiana Gomes de Oliveria and Nielsen, Lars Keld(2013)Plant genome-scale metabolic reconstruction and modellingCurrent Opinion in Biotechnology24 2: 271-277. doi:10.1016/j.copbio.2012.08.007
  10. Dal'Molin, Cristiana Gomes de OliveiraQuek, Lake-EePalfreyman, Robin W. and Nielsen, Lars K. (2011)AlgaGEM - A genome-scale metabolic reconstruction of Algae based on Chlamydomonas reinhardtii genomeBMC Genomics12 S4: s5.1-s5.10. doi:10.1186/1471-2164-12-S4-S5
  11. Dal'Molin, Cristiana Gomes Quek, Lake-EePalfreyman, Robin WilliamBrumbley, Stevens Michael and Nielsen, Lars Keld (2010)C4GEM, a genome-scale metabolic model to study C4 plant metabolismPlant Physiology154 4: 1871-1885. doi:10.1104/pp.110.166488
  12. Dal'Molin, C.G.D.Quek, L.E.Palfreyman, R.W.Brumbley, S.M.and Nielsen, L.K. (2010)AraGEM, a Genome-scale reconstruction of the primary metabolic network in arabidopsisPlant Physiology152 2: 579-589. doi:10.1104/pp.109.148817
  13. Dal'Molin, Cristiana Gomes de Oliveria and Antônio, Regina Vasconcellos (2009)Chromobacterium violaceum ATCC12472: multi-drug and ethidium bromide resistantNature Precedings, .
  14. Gomes de Oliveria, Christina and Porto, Luismar Marques(2005)A kinetic model for bleaching vegetable oilsJournal of the American Oil Chemists' Society82 7: 537-542. doi:10.1007/s11746-005-1106-
  15. McQualter, R. B.Petrasovits, L. A.Gebbie, L. K.Hodson, M. P.Plan, M. R.Blackman D. M.Dal'Molin, C.Brumbley, S. M. and Nielsen, L. K. (2013).A superior catalyst for polyhydroxybutyrate production in sugarcane. In: TABBS 2013: The Australasian Bioenergy and Bioproducts Symposium, Brisbane, QLD, Australia, (). 25 October, 2013.
  16. McQualter, RichardGebbie, LeighDal'Molin, Cristiana G.d.Petrasovits, LarsSnell, K. D.Nielsen, Lars K. and Brumbley, Stevens (2012).Major adjustments in metabolic flux occur to accommodate PHB production in sugarcane. In: The 13th International Symposium on Biopolymers (ISBP 2012), Cairns, Australia, (). 7-10 October.
  17. Brumbley, Stevens M.Petrasovits, Lars A.McQualter, Richard M.Zhao, Lihan, Dal’Molin, Cristiana G. O.Snell, Kristi D. and Nielsen, Lars K. (2010).Increasing Production of Polyhydroxybutyrate in Sugarcane Plastids. In: Plant & Animal Genome XVIII, Town and Country Resort, San Diego, California USA, (). January 9-13.
  18. Brumbley, S. M.Petrasovits, L. A.McQualter, R. B.Zhou, L.Dal'Molin, C. and Nielsen, L. K. (2009).Developing sugarcane as a biofactory to produce plastics. In: Tropical Crops Biotechnology Conference 2009,, Kruger, South Africa, (). 21-25 July 2009.
  19. Dal'Molin, Cristiana G.Quek, Lake-ee and Nielsen, Lars K.(2008).Genome scale metabolic network model of Arabidopsis. In: Health And Sustainability: Metabolic Engineering VII, Puerto Vallarta, Mexico, (). 14-18 September 2008.
  20. Dal'Molin, CQuek, LE and Nielsen, LK (2008).BIOT 273-Genome-scale metabolic network model of Arabidopsis. In: Abstracts of Papers of The American Chemical Society. 236th National Meeting of the American-Chemical-Society, Philadelphia, PA, USA, (). 17-21 August, 2008.
  21. Dal'Molin, Cristiana Gomes de OliveriaQuek, Lake-Ee and Nielsen, Lars (2007).Genome scale model of a plant cell. In: Plant Metabolic Engineering Gordon Research Conference, Tilton School, U.S.A., (). 15-20 July 2007.
  22. Colpani, GustavoDal'Molin, Cristiana Gomes de Oliveira and Porto, Luismar Marques (2005).Construção De Uma Rede De Petri Híbrida para Representação da Via Regulatória da Expressão de Violaceína (Construction of a hybrid Petri network to represent the regulatory expression of violacein). In: Proceedings of the Chemical Engineer Conference (VI COBEQ). Chemical Engineer Conference (VI COBEQ), Brazil, (). 2005.
  23. Dal'Molin, C. G. O., Porto, L. M. and Antonio, R. V. (2005).Modeling of C-terminal domain of CviR and its role on the Regulation of vioABCD operon by Quorum sensing in Chromobacterium violaceum. In: 1st International Conference of the Brazilian Association of Bioinformatics and Computational Biology, Caxambu, MG, Brazil, (). 4-7 October 2005.
  24. Dal'Molin, Cristiana Gomes de OliveiraPorto, Luismar Marquesand António, Regina Vasconcellos (2005).Regulation of violacein biosynthesis and quorum sensing signaling in Chromobacterium violaceum. In:Annual Meeting of Brazilian Society of Biochemistry and Molecular Biology (SBBq), Aguas de Lindóia, São Paulo, Brazil, (). July 2005.
  25. Dal'Molin, Cristiana G. D.O. (2004).Regulatory mechanism to violacein production by quorum sensing signaling in Chromobacterium violaceum. In: XV Brazilian Congress of Chemical Engineering. Brazilian Chemical Engineering Conference, (COBEQ), Curitiba, Brazil, (). September 26 - 29, 2004.
  26. Dal'Molin, Cristiana Gomes de Olivera and Porto, Luismar Marques (2003).Kinetic growth and violacein production by Chromobacterium violaceum using glycerol e glucose as carbon source. In: Proceedings of the XIV Nacional Symposium of Fermentation. XIV Nacional Symposium of Fermentation, Florianopolis, Brazil, (). 2003.