Prior to joining AIBN in 2018, Matthias completed his Master’s degree in Biotechnology at Lund University, Sweden and his undergraduate in Molecular and Applied Biotechnology at the RWTH Aachen in Germany. Additionally, he spent time at the Fraunhofer Institute for Molecular Biotechnology, located in the US.

Chinese hamster ovary (CHO) cells are the dominant production platform for biopharmaceutical manufacturing. Unfortunately, processes using CHO cells are costly, leading to an expensive product and thus limiting accessibility of therapies to the broader population. Focussing on emerging high cell density perfusion cultures, we aim to progress from pattern observations to a systems biology view. Proteomic and metabolomic profiles are generated under different process conditions and analysed on a genome wide level utilising models. Once metabolic shifts are understood, they can be utilised to guide rational genetic engineering approaches.

Key publications

Krithika Ravi, Omar Y. Abdelaziz, Matthias Nöbel, Javier García-Hidalgo, Marie F. Gorwa-Grauslund, Christian P. Hulteberg, Gunnar Lidén. Bacterial conversion of depolymerized Kraft lignin. Biotechnology for Biofuels 12, 56 (2019).

Featured projects Duration
Rational Improvement for High Density CHO Cell Culture