ARC DP Mimicking the perivascular niche with boronolectin-based biomaterials

Autologous adult stem cell products have the potential to significantly change the way we age or recover from injury. Achieving this potential requires manufacturing methods that consistently make enough high-quality, functional cells for each recipient in a cost-effective manner. By discovering biomaterials that can mimic critical components of the 'niche' in which they reside and specifically engage their 'sugar-coated' surfaces, this project aims to create novel, scalable, and translatable culture substrates that achieve long-term, multipotent expansion of adult stem cells. Outcomes of this project will be of substantive benefit to the burgeoning cell-manufacturing industry and significantly impact on our healthspan and quality of life.