Project Summary

Ataxia-Telangiectasia (A-T) is caused by mutations in the ATM kinase, a protein involved in DNA break repair and oxidative stress regulation. We have generated iPSC from human patients with A-T to study the degeneration of the hindbrain in this disease. We use CRISPR-Cas9 genome editing tools to correct and introduce mutations in ATM in IPSC and multi-omics and advanced imaging technologies to probe the underlying molecular processes.

Research Group

Wolvetang Group

Keywords

iPSC, Ataxia-Telangiectasia, DNA damage, ATM, differentiation, Ageing, reporters, CRISPR

Student Projects

Neuronal activity dependent DNA DSBs, a novel pathogenic mechanism for A-T

Project members

Lead Investigator


Professor Ernst Wolvetang

Senior Group Leader
Wolvetang Group
UQ-StemCARE Director

Researchers Involved


Dmitry Ovchinnikov

Research Fellow
Wolvetang Group