Brain organoids for modeling human neuropathogensis
Duration:
January 2017–January 2019
Project Summary
In this project variously functionlised hydrogels as well as conventional stirred bioreactors will be used to generate brain organoids from control, neurological disease and artificially aged human iPSC. Various optogenetic tools as well as reporter gene technology will be deployed to interrogate neuronal connectivity and the gene regulatory networks that underlie disease and ageing.
Research Group
Keywords
iPSC, optogenetics, neuronal connectivity, neurons, differentiation, Ageing, organoids, CRISPR
Student Projects
Probing connectivity and neuro-pathogenesis in human brain organoids
