Project Summary

In this project variously functionlised hydrogels as well as conventional stirred bioreactors will be used to generate brain organoids from control, neurological disease and artificially aged human iPSC. Various optogenetic tools as well as reporter gene technology will be deployed to interrogate neuronal  connectivity and the gene regulatory networks that underlie disease and ageing. 

A cortical brain organoid

Research Group

Wolvetang Group

Keywords

iPSC, optogenetics, neuronal connectivity, neurons, differentiation, Ageing, organoids, CRISPR

Student Projects

Probing connectivity and neuro-pathogenesis in human brain organoids

Project members

Lead Investigator


Professor Ernst Wolvetang

Senior Group Leader
Wolvetang Group
UQ-StemCARE Director

Researchers Involved