The loss of appetite is observed in patients with motor neuron disease (MND). This is clinically important, as energy deficits and weight loss are associated with faster disease progression and earlier death. This project aims to identify the impact of MND on the hypothalamus, a small area of the brain that consists of complex nutrient-sensing pathways that regulate appetite, and how this may contribute to functional deficits throughout the brain. This project aims to use advanced imaging and transcriptomic techniques to provide a biological basis for the loss of appetite in patients with MND, which will enhance understanding of the disease, and provide insights to better manage care strategies aimed at improving quality and duration of life.


Motor Neurone Disease Research Australia PhD Top-up Grant 2022 - 2024

Project members


Jeryn Chang

Phd Candidate
Ngo Group