Project summary

In-situ monitoring of specific biomarkers, such as reactive oxygen species, ions, proteins (including enzyme),  at the molecular level is key to understanding their roles in physiological and pathological processes, and plays fundamental roles in early prediction of diseases treatment. Even so, tracking these ultrasmall biomolecules within body remains a challenge for researchers and clinicians due to the lack of rapid and accurate detection methods. This project will establish a series methods for visualization and quantification the levels of biomarkers in vivo during diseases diagnosis and treatment. A new family of responsive biosensors will be developed for the detection of these biomarkers sensitively and selectively by rational design and exploring the molecular and nanoparticle-based materials. Real-time monitoring of biomarkers within body will be quantitatively achieved by collecting the evolution of optical photons, relaxivity (MRI), and acoustic waves as the read-out signals. Visualization of biomarkers in diagnosis and treatment of liver diseases will be employed as the model for establishing of the biosensing platform. The successful development of the biosensors not only holds great promise for the early diagnosis and prediction of diseases, but also provides the progressive information for post-therapy monitoring. of RNAi technology, to provide resistance against pests and pathogens.

Research Group

Xu Group

Keywords

Nanomaterials, Nanobiotechnology, Health, Responsive Biosensor, Bioimaging, Biomarker Detection, Disease Treatment

Available Student Projects

Monitoring diseases and treatment progress with a responsive biosensor

 

 

 

 

 

 

 

Project members

Lead Investigators

Professor Zhi Ping (Gordon) Xu

Senior Group Leader
Xu Group

Researchers Involved

Dr Run Zhang

Research Fellow
Xu Group