Probing molecular determinants of Ageing using human IPSC and reprogramming models
Duration:
January 2017–January 2019
Project Summary
In this project CRISPR technology will be used to engineer accellerated ageing models in human iPSC that subsequently will be subjected to neuronal differentiation in 2D and 3D (brain organoid) settings. Simultaneously isogenic somatic cells will be directly reprogrammed into equivalent neuronal cell types to probe the genetic and epigenetic drivers of in vitro observable ageing phenomena.
Research Group
Keywords
iPSC, Reprogramming, differentiation, epigenetics, Ageing, neurons, organoids, CRISPR
Student Projects
CRISPR enabled screening for modulators of ageing in iPSC derived cell types
