My research focused in anaerobic methane fermentation, systems metabolic engineering is the key methodology applied in the project. We reconstruct a genome-scale metabolic model to understand the metabolism of anaerobic methanotrophic archaea (Methanoperendens nitroreducens), gain insight into the pathway and the chemistry within the network. The mechanisms of M. nitroreducens energy conservation improves our understanding of anaerobic methane methanotrophy, and the application of thermodynamic metabolic flux analysis achieves a better understanding of the metabolism which operates at the thermodynamic edge of feasibility. Furthermore, by using the genome-scale model to integrate omics data can also improve in-silico metabolic simulations and compare the metabolic pathway shift under different conditions.  

Project members

Dr Esteban Marcellin Saldana

Group Leader
Marcellin Group

Bingqing He

PhD Student
Marcellin Group

Professor Zhiguo Yuan

Advanced Water Management Centre