AIBN Seminar Series Imaging Morphology and Function of Cerebral Small Vessels at 3 and 7T

We are pleased to present Dr. Danny JJ Wang to speak on the topic Imaging Morphology and Function of Cerebral Small Vessels at 3 and 7T.

When: 2nd May 2024

Where:AIBN Level 1 Seminar room or online via zoom https://uqz.zoom.us/j/85650479925

Time: 11am-12pm

Abstract:

Cerebral small vessel disease (cSVD) is the most common vascular cause of dementia. However, cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing in vivo imaging technologies. During the past decade, our group at the Laboratory of FMRI Technology (LOFT) has spearheaded the development of a suite of MRI techniques at 3 and 7T for in vivo imaging and quantification of the morphology and function of cerebral small vessels, including high-resolution black blood MRI, arterial spin labeled (ASL) perfusion and diffusion-weighted ASL for mapping BBB water exchange. In this talk, I will summarize recent technical development and applications of these techniques in aging, cerebral SVD, cognitive decline and dementia. I will also present laminar perfusion and metabolic imaging at 7T for understanding neural circuit function across cortical layers.

Bio:

Dr. Danny JJ Wang is Professor of Neurology and Radiology, Director of Imaging Technology Innovation at the Stevens Neuroimaging and Informatics institute, University of Southern California (USC), as well as head of the Laboratory of Functional MRI technology (LOFT www.loft-lab.org). During the past 25 years, his research has been focused on the technical development and clinical translations of novel functional and physiological MRI technologies, in particular noninvasive blood flow/perfusion imaging using arterial spin labeling (ASL). He is a recognized expert in perfusion and functional MRI and have extensive experience in clinical applications related to cerebrovascular disorders, dementia and neurodevelopment, as well as development at ultrahigh field. He has also been supporting the scientific community by disseminating ASL sequences to >300 imaging research centers around the world. To date, Dr. Wang has published over 240 peer reviewed publications and 30 review chapters with an h-index of 78 and over 22,000 citations. He currently serves as the chair of International Society of Magnetic Resonance in Medicine (ISMRM) perfusion study group, and was elected Fellow of ISMRM in 2022. Dr. Wang also initiated the 7T Translational Alliance of North America (7TANA.org) in 2023 that consists of 32+ 7T sites in the US and Canada