We are pleased to present Distinguished Professor Yin Xiao  to speak on The interplay between hemostasis and immune response in biomaterial development for tissue healing

Date: Thursday 01, September

Time: 12:30 pm

Venue: AIBN Level 1 Seminar room or online via Zoom

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Treatment of large bone defects, particularly bone non-union, remains a clinical challenge. The gold-standard bone substitute continues to be an autologous bone graft, which is difficult to be replaced with synthetic biomaterials. Considering these aspects, strategies should be formulated to develop advanced materials for functional bone regeneration. Recent studies have revealed that hematoma (the first tissue structure formed at the bone injury site) plays an essential role in bone healing. Hematoma consists of a fibrin clot, infiltrated immune cells, and tissue progenitor cells. It bridges the bone defect and provides a microenvironment for the interplay between hemostasis and the immune systems. Moreover, an ideal fibrin structure with appropriate fiber thickness and density could facilitate bone regeneration, and biomaterial implantation could affect fibrin structure. Meanwhile, immunoregulation plays an essential role in bone healing. In particular, materials inducing a shift from inflammatory to anti-inflammatory phenotypes in immune cells show enhanced osteoinductivity. More importantly, the interaction between hemostasis and the immune system should play a vital part in bone regeneration by determining fibrin structure and bone healing microenvironment. Coagulants-triggered inflammation could, in turn, facilitate coagulation cascades, which form positive feedback to amplify both processes. Meanwhile, anti-coagulants neutralize coagulation and inhibit inflammation, thereby controlling the clotting and inflammation to prevent thrombosis. The balance between coagulation–inflammation and anti-coagulation–anti-inflammation plays a determinant role in the fibrin structure and fibrinolysis process. The inflammation could be “quenched” gradually during this process, whereby a highly effective microenvironment for bone regeneration can be generated. There are limited biomaterial studies targeting bone-healing hematoma, particularly the hemostasis–immune interplay. It proposes potential strategies to develop functional materials to generate a highly effective bone healing hematoma by modulating the hemostasis–immune interplay to maintain the balance between coagulation–inflammation and anti-coagulation–anti-inflammation.



Professor Yin Xiao, a dental specialist (BDSc 1986 and MDSc 1991), started his research career in 2000 (Ph.D. from the University of Queensland) and is a tenured Distinguished Professor in Dentistry and Medicine at Griffith University. He was a full professor at Queensland University of Technology (QUT) since 2012 and an associate professor from 2005 at QUT. He is the Founder, and the Director of the Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), established in 2013, and the Joint Research Centre of functional biomaterials for tissue and organ replacement. His work has predominantly focused on bone, biomaterials, stem cells, dentistry, osteoarthritis, and tissue engineering. He initiated the concept of osteoimmunology in bone biomaterial development and introduced the "Materiobiology" in M. Phil's training courses at QUT. He has authored more than 340 journal papers, three books, and 23 book chapters. His H index is 73, and his work has been cited more than 20,000 times. He was named one of the top 250 researchers in Australia and the field leader in Biomedical Technology in 2019 and 2021 by Australian Research Magazine.

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The AIBN Seminar series showcases a range of seminars across different topics and disciplines