Australian Institute for Bioengineering and Nanotechnology

Dr Wenyi Gu

Research Fellow
Monteiro Group
+61 7 334 64168

Dr Wenyi Gu specialises in drug delivery and nanomedicine

His major research focuses on drug delivery and cancer therapy. In conjunction with it, he is interests in researches of oncogenes, cancer stem cells, targeted delivery systems, cancer cell biomarkers, and cancer immunotherapy. His recent research is more concentrated on RNAi delivery with nanoparticles and on identifying therapeutic targets for cancer stem cells and exploring novel therapeutic approaches including using RNAi and nature compounds to inhibit cancer stem cell growth. 

Dr. Wenyi Gu’s early education was conducted in China which include his undergraduate and master’s degrees in veterinary medicine. In 1996, he migrated to Australia and pursued his PhD study in biochemistry & molecular biology at the Australian National University (ANU). After a short period of work at John Curtin Medical School ANU as a junior scientist, he moved to Brisbane in 2001 for his post-doc at the University of Queensland and is currently a post-doctoral research fellow at the AIBN. He held a Peter Doherty Fellowship (2006-2009) and was further supported by NHMRC to spend 7 months at Harvard University as a visiting fellow in 2008. Since his post-doctoral research he has been working in the area of using RNAi to treat viral diseases and cancers. He also has a strong background in immunology and vaccine development.

Key Publications

  1. Gu, Wenyi, McMillan, Nigel and Yu, Chengzhong (2015).Silencing of E6/E7 expression in cervical cancer stem-like cells. In Daniel Keppler and Athena W. Lin (Ed.), Cervical cancer: methods and protocols (pp. 173-182) New York, NY United States: Springer. doi:10.1007/978-1-4939-2013-6_12
  2. Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi(2013).Mesenchymal stem cells and nano-structured surfaces. In Turksen, K (Ed.), Stem Cell Nanotechnology: Methods and Protocols(pp. 133-148) New York, NY, United States: Humana Press. doi:10.1007/7651_2013_30
  3. Gu, W., Putral, L. and McMillan, N. A. J. (2008).siRNA and shRNA as anti-cancer agents in a cervical cancer model. In J. M. Walker (Ed.), RNAi : design and application(pp. 159-172) Totowa, N.J., U.S.A.: Humana Press, Inc..
  4. Zheng, Yang, Wang, Zhao, Xiong, Xianbin, Zhong, Yi, Zhang, Wei, Dong, Yibo, Li, Jialiang, Zhu, Zaiou, Zhang, Wei, Wu, Heming, Gu, Wenyi, Wu, Yunong, Wang, Xiang and Song, Xiaomeng (2019)Membrane-tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinoma. Journal of Cellular Physiology, 234 5: 5940-5952. doi:10.1002/jcp.27022
  5. Gu, Wenyi, Sun, Surong, Kahn, Andrew, Dacus, Dalton, Wendel, Sebastian O., McMillan, Nigel and Wallace, Nicholas A. (2019)Cervical cancer cell lines are sensitive to sub-erythemal UV exposure. Gene, 688 44-53. doi:10.1016/j.gene.2018.11.079
  6. Chen, Mingshui, Sharma, Aditi, Lin, Yanling, Wu, Yanheng, He, Qi, Gu, Yushu, Xu, Zhi Ping, Monteiro, Michael and Gu, Wenyi (2019)Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells. BMC Cancer, 19 1: 153. doi:10.1186/s12885-019-5364-3
  7. Gu, Wenyi, Wang, Lihui, Wu, Yanheng and Liu, Jun-Ping (2019)Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells. Clinical and Experimental Pharmacology and Physiology, 462: 105-115. doi:10.1111/1440-1681.13056
  8. Li, Mengxue, Sultanbawa, Yasmina, Xu, Zhi Ping, Gu, Wenyi, Chen, Weiyu, Liu, Jianyong and Qian, Guangren (2019)High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide. Colloids and Surfaces B: Biointerfaces, 174 435-442. doi:10.1016/j.colsurfb.2018.11.035
  9. Wu, Yanheng, Gu, Wenyi, Li, Li, Chen, Chen and Xu, Zhi (2019)Enhancing PD-1 gene silence in T lymphocytes by comparing the delivery performance of two inorganic nanoparticle platforms. Nanomaterials, 9 2: 159. doi:10.3390/nano9020159
  10. Wu, Yilun, Gu, Wenyi and Xu, Zhi Ping (2019)Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platform. Nanomedicine, 14 1: 77-92. doi:10.2217/nnm-2018-0252
  11. Tao, Lin, Amanguli, A., Li, Feng, Wang, Ying Hong, Yang, Lan, Mohemaiti, Meiliguli, Zhao, Jin, Zou, Xiao Guang, Saimaiti, Abudukeyoumu, Abudu, Mirensha, Maimaiti, Mikairemu, Chen, Shi Yan, Abudukelimu, Ruxianguli, Maimaiti, Ayinuer, Li, Shu Gang, Zhang, Wei, Aizimu, Ayinuer, Yang, An Qiang, Wang, Ju, Pang, Li Juan, Cao, Yu Guang, Gu, Wen Yi and Zhang, Wen Jie (2018)Cervical Screening by Pap Test and Visual Inspection Enabling Same-Day Biopsy in Low-Resource, High-Risk Communities. Obstetrics and gynecology, 132 6: 1421-1429. doi:10.1097/AOG.0000000000002973
  12. Yan, Shiyu, Xu, Kewei, Li, Li, Gu, Wenyi, Rolfe, Barbara E. and Xu, Zhi P. (2018)The pathways for layered double hydroxide nanoparticles to enhance antigen (cross)-presentation on immune cells as adjuvants for protein vaccines. Frontiers in Pharmacology, 91060. doi:10.3389/fphar.2018.01060
  13. Gu, Wenyi, Bobrin, Valentin A., Chen, Sung-Po R., Wang, Zhao, Schoning, Jennifer P., Gu, Yushu, Chen, Weiyu, Chen, Mingshui, Jia, Zhongfan and Monteiro, Michael J. (2018)Biodistribution of PNIPAM-Coated Nanostructures Synthesized by the TDMT Method. Biomacromolecules, . doi:10.1021/acs.biomac.8b01196
  14. Wu, Yanheng, Gu, Wenyi, Chen, Chen, Do, Son Trong and Xu, Zhi Ping (2018)Optimization of formulations consisting of layered double hydroxide nanoparticles and small interfering RNA for efficient knockdown of the target gene. ACS Omega, 3 5: 4871-4877. doi:10.1021/acsomega.8b00397
  15. Wang, Jie, Gu, Wenyi and Chen, Chen (2018)Knocking down insulin receptor in pancreatic beta cell lines with lentiviral-small hairpin RNA reduces glucose-stimulated insulin secretion via decreasing the gene expression of insulin, GLUT2 and Pdx1. International Journal of Molecular Sciences, 19 4: 985. doi:10.3390/ijms19040985
  16. Wang, Ning, Liu, Zi-Han, Zou, Hong, Pang, Li-Juan, Gu, Wen-Yi, Hu, Jian-Ming, Li, Dong-Mei, Zhao, Jin, Zhang, Jun, Liu, Chun-Xia, Zhang, Wen-Jie, Qi, Yan and Li, Feng (2018)Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcoma. Clinical and Experimental Pharmacology & Physiology, 45 7: 675-682. doi:10.1111/1440-1681.12936
  17. Zheng, Yang, Wang, Zhao, Ding, Xu, Zhang, Wei, Li, Gang, Liu, Laikui, Wu, Heming, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2018)A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma. Cancer Cell International, 18 1: 1-15. doi:10.1186/s12935-017-0496-5
  18. Liu, Tingting, Liu, Lihong, Gu, Wenyi, Liu, Jian and Liu, Shaomin(2018)One-pot synthesis of raspberry-like mesoporous silica nanospheres. Journal of Nanoscience and Nanotechnology, 18 1: 401-406. doi:10.1166/jnn.2018.14607
  19. Li, Kelu, Ma, Hongmei, Zheng, Xiuyan, Hu, Yali, Wang, Yue, Zhang, Kunpeng, Chen, Jiahan, Qi, Yan, Jiang, Jinfang, Pang, Lijuan, Tao, Lin, Gu, Wenyi, Li, Feng and Zou, Hong (2018)Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression. International Journal of Clinical and Experimental Pathology, 11 3: 1707-1711.
  20. Zheng, Yang, Wang, Zhao, Ding, Xu, Dong, Yibo, Zhang, Wei, Zhang, Wei, Zhong, Yi, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2017)Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma. Cell Proliferation, 51 3: e12424. doi:10.1111/cpr.12424
  21. Yan, Shiyu, Gu, Wenyi, Zhang, Bing, Rolfe, Barbara E and Xu, Zhi Ping (2017)High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations. Dalton Transactions, 47 9: 2956-2964. doi:10.1039/c7dt03725b
  22. Movahedi, Fatemeh, Li, Li, Gu, Wenyi and Xu, Zhi Ping (2017)Nanoformulations of albendazole as effective anticancer and antiparasite agents. Nanomedicine, 12 20: 2555-2574. doi:10.2217/nnm-2017-0102
  23. Wu, Yilun, Gu, Wenyi, Tang, Jie and Xu, Zhi Ping (2017)Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery. Journal of Materials Chemistry B, 534: 7194-7203. doi:10.1039/c7tb01635b
  24. Qi, Yan, Wang, Ning, He, Yonglai, Zhang, Jun, Zou, Hong, Zhang, Wenjie, Gu, Wenyi, Huang, Yalan, Lian, Xiaojuan, Hu, Jianming, Zhao, Jin, Cui, Xiaobin, Pang, Lijuan and Li, Feng (2017)Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells. PLoS One, 12 8: e0182680. doi:10.1371/journal.pone.0182680
  25. Liu, Hangrui, Song, Fan, Gu, Wenyi, Feng, Jinian, Cai, Wanzhi and Shao, Renfu (2017)Novel insights into mitochondrial gene rearrangement in thrips (Insecta: Thysanoptera) from the grass thrips, Anaphothrips obscurus. Scientific Reports, 7 1: 4284. doi:10.1038/s41598-017-04617-5
  26. Li, Li, Zhang, Run, Gu, Wenyi and Ping, Zhi (2017)Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 14 7: 2355-2364. doi:10.1016/j.nano.2017.06.006
  27. Wu, Yanheng, Chen, Mingshui, Wu, Peihong, Chen, Chen, Xu, Zhi Ping and Gu, Wenyi (2017)Increased PD-L1 expression in breast and colon cancer stem cells. Clinical and Experimental Pharmacology and Physiology, 44 5: 602-604. doi:10.1111/1440-1681.12732
  28. Qi, Yan, Huang, Yalan, Pang, Lijuan, Gu, Wenyi, Wang, Ning, Hu, Jianming, Cui, Xiaobin, Zhang, Jun, Zhao, Jin, Liu, Chunxia, Zhang, Wenjie, Zou, Hong and Li, Feng (2017)Prognostic value of the MicroRNA-29 family in multiple human cancers: a meta-analysis and systematic review. Clinical and Experimental Pharmacology and Physiology, 44 4: 441-454. doi:10.1111/1440-1681.12726
  29. Schoning, Jennifer Petra, Monteiro, Michael and Gu, Wenyi (2017)Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α. Clinical and Experimental Pharmacology & Physiology, 44 2: 153-161. doi:10.1111/1440-1681.12693
  30. Singhania, Richa, Pavey, Sandra, Payne, Elizabeth, Gu, Wenyi, Clancy, Jennifer, Jubair, Luqman, Preiss, Thomas, Saunders, Nicholas and McMillan, Nigel A. J. (2016)Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859 8: 1034-1042. doi:10.1016/j.bbagrm.2016.06.005
  31. Prasadam, Indira, Batra, Jyotsna, Perry, Samuel, Gu, Wenyi, Crawford, Ross and Xiao, Yin (2016)Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis. Calcified Tissue International, 99 1: 43-55. doi:10.1007/s00223-016-0125-7
  32. Li, Li, Gu, Zi, Gu, Wenyi, Liu, Jian and Xu, Zhi Ping (2016)Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science, 47047-55. doi:10.1016/j.jcis.2016.02.042
  33. Zou, Hong, Li, Li, Garcia Carcedo, Ines, Xu, Zhi Ping, Monteiro, Michael and Gu, Wenyi (2016)Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/ mTOR dual inhibitor BEZ235 through apoptosis. International Journal of Nanomedicine, 11 1947-1958. doi:10.2147/IJN.S100744
  34. Chen, Weiyu, Zhang, Bing, Mahony, Timothy, Gu, Wenyi, Rolfe, Barbara and Xu, Zhi Ping (2016)Efficient and durable vaccine against Intimin β of Diarrheagenic E. Coli induced by clay nanoparticles. Small, 12 12: 1627-1639. doi:10.1002/smll.201503359
  35. Li, L., Gu, Z., Gu, W. Y. and Xu, Z. P. (2016)Direct synthesis of layered double hydroxide nanosheets for efficient siRNA delivery. RSC Advances, 6 98: 95518-95526. doi:10.1039/c6ra19225d
  36. Yu, Meihua, Niu, Yuting, Zhang, Jun, Zhang, Hongwei, Yang, Yannan, Taran, Elena, Jambhrunkar, Siddharth, Gu, Wenyi, Thorn, Peter and Yu, Chengzhong (2015)Size-dependent gene delivery of amine-modified silica nanoparticles. Nano Research, 9 2: 291-305. doi:10.1007/s12274-015-0909-5
  37. Chen, Jiezhong, Shao, Renfu, Li, Feng, Monteiro, Michael, Liu, Jun-Ping, Xu, Zhi Ping and Gu, Wenyi (2015)PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells. Clinical and Experimental Pharmacology and Physiology, 42 12: 1317-1326. doi:10.1111/1440-1681.12493
  38. Gu, Wenyi, Prasadam, Indira, Yu, Meihua, Zhang, Fengxia, Ling, Patrick, Xiao, Yin and Yu, Chengzhong (2015)Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. BMC Cancer, 15 1: 1-11. doi:10.1186/s12885-015-1614-1
  39. Chen, Jiezhong, Gu, Wenyi, Yang, Lei, Chen, Chen, Shao, Renfu, Xu, Kewei and Xu, Zhi Ping (2015)Nanotechnology in the management of cervical cancer. Reviews in Medical Virology, 25 S1: 72-83. doi:10.1002/rmv.1825
  40. Li, Li, Gu, Wenyi, Liu, Jian, Yan, Shiyu and Xu, Zhi Ping (2015)Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery. Nano Research, 8 2: 682-694. doi:10.1007/s12274-014-0552-6
  41. Yan, Shiyu, Rolfe, Barbara E., Zhang, Bing, Mohammed, Yousuf H., Gu, Wenyi and Xu, Zhi P. (2014)Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG. Biomaterials, 35 35: 9508-9516. doi:10.1016/j.biomaterials.2014.07.055
  42. Chen, Jiezhong, Shao, Renfu, Li, Li, Xu, Zhi Ping and Gu, Wenyi(2014)Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways. International Journal of Nanomedicine, 9 1: 3403-3411. doi:10.2147/IJN.S61633
  43. Pan, Q. F., Li, W. T., Dong, H. C., Chen, Y. Z., Yin, L., Liu, W., Wang, W. W., Liu, D., Li, S. G., Gu, W. Y., Chen, J. Z., Yang, L., Zhang, W. J. and Li, F. (2014)PTEN hypermethylation profiles of Chinese Kazakh patients with esophageal squamous cell carcinoma. Diseases of the Esophagus, 27 4: 396-402. doi:10.1111/dote.12106
  44. Tan, Xiaohua, Yang, Li, Xian, Lingling, Huang, Jin, Di, Chunhong, Gu, Wenyi, Guo, Shuli and Yang, Lei (2014)ATP- binding cassette transporter A1 ( ABCA1) promotes arsenic tolerance in human cells by reducing cellular arsenic accumulation. Clinical and Experimental Pharmacology and Physiology, 41 4: 287-294. doi:10.1111/1440-1681.12219
  45. Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu and Xu, Zhi P. (2014)Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. Biomaterials, 35 10: 3331-3339. doi:10.1016/j.biomaterials.2013.12.095
  46. Cui, Xiaobin, Zhao, Zhimin, Liu, Dong, Guo, Tao, Li, Su, Hu, Jianming, Liu, Chunxia, Yang, Lan, Cao, Yuwen, Jiang, Jinfang, Liang, Weihua, Liu, Wei, Li, Shugang, Wang, Lianghai, Wang, Lidong, Gu, Wenyi, Wu, Chuanyue, Chen, Yunzhao and Li, Feng (2014)Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. Journal of Experimental and Clinical Cancer Research, 33 1: . doi:10.1186/1756-9966-33-20
  47. Hartono, Sandy B., Yu, Meihua, Gu, Wenyi, Yang, Jie, Strounina, Ekaterina, Wang, Xiaolin, Qiao, Shizhang and Yu, Chengzhong(2014)Synthesis of multi-functional large pore mesoporous silica nanoparticles as gene carriers. Nanotechnology, 25 5: 055701.1-055701.13. doi:10.1088/0957-4484/25/5/055701
  48. Chen, Zetao, Wu, Chengtie, Gu, Wenyi, Klein, Travis, Crawford, Rossand Xiao, Yin (2014)Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials, 35 5: 1507-1518. doi:10.1016/j.biomaterials.2013.11.014
  49. Niu, Yuting, Yu, Meihua, Hartono, Sandy B., Yang, Jie, Xu, Hongyi, Zhang, Hongwei, Zou, Jun, Zou, Jin, Dexter, Annette, Gu, Wenyi and Yu, Chengzhong (2013)Nanoparticles mimicking viral surface topography for enhanced cellular delivery. Advanced Materials, 25 43: 6233-6237. doi:10.1002/adma.201302737
  50. Cui, Xiao-Bin, Chen, Yun-Zhao, Pang, Xue-lian, Liu, Wei, Hu, Jian-Ming, Li, Shu-Gang, Yang, Lan, Zhang, Wen-Jie, Liu, Chun-xia, Cao, Yu-wen, Jiang, Jin-Fang, Gu, Wen-Yi, Pang, James, Yang, Lei, Yuan, Xiang-Lin, Yu, Shi-Ying and Li, Feng (2013)Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. Gene, 530 2: 315-322. doi:10.1016/j.gene.2013.08.057
  51. Prasadam, Indira, Farnaghi, Saba, Feng, Jian Q., Gu, Wenyi, Perry, Samuel, Crawford, Ross and Xiao, Yin (2013)Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: Role of integrinβ1 and focal adhesion kinase signaling cues. Arthritis Research & Therapy, 15 5: . doi:10.1186/ar4333
  52. Chen, Yun-Zhao, Cui, Xiao-Bin, Hu, Jian-Ming, Zhang, Wen Jie, Li, Shu-Gang, Yang, Lan, Shen, Xi-Hua, Liu, Chun-Xia, Pan, Qing-Fang, Yu, Shi-Ying, Yuan, Xiang-Lin, Yang, Lei, Gu, Wen-Yi, Chen, Jie-Zhong, Wang, Li-Dong and Li, Feng (2013)Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness. Apmis, 121 10: 908-918. doi:10.1111/apm.12095
  53. Gu, Wenyi, Jia, Zhongfan, Truong, Nghia P., Prasadam, Indira, Xiao, Yin and Monteiro, Michael J. (2013)Polymer nanocarrier system for endosome escape and timed release of siRNA with complete gene silencing and cell death in cancer cells. Biomacromolecules, 14 10: 3386-3389. doi:10.1021/bm401139e
  54. Truong, Nghia P., Gu, Wenyi, Prasadam, Indira, Jia, Zhongfan, Crawford, Ross, Xiao, Yin and Monteiro, Michael J. (2013)An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications, 4 1: . doi:10.1038/ncomms2905
  55. Yan, Shiyu, Gu, Wenyi and Xu, Zhi Ping (2013)Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses. Journal of Colloid and Interface Science, 395 1: 1-10. doi:10.1016/j.jcis.2012.11.061
  56. Tang, Tao, Wong, Hoi Kin, Gu, Wenyi, Yu, Mei-yung, To, Ka-Fai, Wang, Chi Chiu, Wong, Yick Fu, Cheung, Tak Hong, Chung, Tony Kwok Hung and Choy, Kwong Wai (2013)MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecologic Oncology, 129 1: 199-208. doi:10.1016/j.ygyno.2012.12.043
  57. Nguyen, Tran T. D., Nghia, Truong P., Gu, Wenyi, Jia, Zhongfan, Cooper, Matthew A. and Monteiro, Michael J. (2013)Timed-release polymer nanoparticles. Biomacromolecules, 142: 495-502. doi:10.1021/bm301721k
  58. Gu, Wenyi, Chen, Chen and Zhao, Kong-Nan (2013)Obesity-associated endometrial and cervical cancers. Frontiers in Bioscience, 5 1: 109-118.
  59. Gu, Wenyi, Wu, Chengtie, Chen, Jiezhong and Xiao, Yin (2013)Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration. International Journal of Nanomedicine, 8 2305-2317. doi:10.2147/IJN.S44393
  60. Yu, Meihua, Jambhrunkar, Siddharth, Thorn, Peter, Chen, Jiezhong, Gu, Wenyi and Yu, Chengzhong (2013)Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale, 5 1: 178-183. doi:10.1039/c2nr32145a
  61. Qian, Kun, Liu, Fang, Yang, Jie, Huang, Xiaodan, Gu, Wenyi, Jambhrunkar, Siddharth, Yuan, Pei and Yu, Chengzhong (2013)Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymers. RSC Advances, 334: 14466-14472. doi:10.1039/c3ra41332b
  62. Niu, Yuting, Popat, Amirali, Yu, Meihua, Karmakar, Surajit, Gu, Wenyiand Yu, Chengzhong (2012)Recent advance in silica-based engineered nanoparticles for gene therapy. Therapeutic Delivery, 3 10: 1217-1237. doi:10.4155/tde.12.98
  63. Yu, Meihua, Zhou, Liang, Zhang, Jun, Yuan, Pei, Thorn, Peter, Gu, Wenyi and Yu, Chengzhong (2012)A simple approach to prepare monodisperse mesoporous silica nanospheres with adjustable sizes. Journal of Colloid and Interface Science, 376 1: 67-75. doi:10.1016/j.jcis.2012.03.014
  64. Hartono, Sandy B., Gu, Wenyi, Kleitz, Freddy, Liu, Jian, He, Lizhong, Middelberg, Anton P. J., Yu, Chengzhong, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012)Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. ACS Nano, 6 3: 2104-2117. doi:10.1021/nn2039643
  65. Qian, Kun, Gu, Wenyi, Yuan, Pei, Liu, Fang, Wang, Yunhua, Monteiro, Michael and Yu, Chengzhong (2012)Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheres. Small, 8 2: 231-236. doi:10.1002/smll.201101770
  66. Gislette, Tiphaine, Zhao, Kong-Nan, Gu, Wenyi and Chen, Jiezhong(2012)The possible mechanisms for β-glucans to prevent atherosclerotic lesions. Current Bioactive Compounds, 8 2: 146-150. doi:10.2174/157340712801784796
  67. Gu, Wenyi, Chen, Jeizhong, Yang, Lei and Zhao, Kong-Nan (2012)TNF-alpha promotes IFN-gamma-induced CD40 expression and antigen process in Myb-transformed hematological cells. The Scientific World Journal, 2012 621969.1-621969.11. doi:10.1100/2012/621969
  68. Gu, W., Yeo, E., McMillan, N. and Yu, C. (2011)Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability. Cancer Gene Therapy, 18 12: 897-905. doi:10.1038/cgt.2011.58
  69. Chen, Jiezhong, Gu, Wenyi and Zhao, Kongnan (2011)The role of PI3K/Akt pathway in beta-glucan-induced dendritic cell maturation. International Immunopharmacology, 11 4: 529-529. doi:10.1016/j.intimp.2011.01.027
  70. Gu, Wenyi, An, Jiyuan, Ye, Ping, Zhao, KongNan and Antonsson, Annika (2011)Prediction of conserved microRNAs from skin and mucosal human papillomaviruses. Archives of Virology, 156 7: 1161-1171. doi:10.1007/s00705-011-0974-3
  71. Gu, Wenyi, Payne, Elizabeth, Sun, Surong, Burgess, Melinda and McMillan, Nigel A. J. (2011)Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs. Cancer Gene Therapy, 18 3: 219-227. doi:10.1038/cgt.2010.72
  72. Ding, Jianmin, Doorbar, John, Li, Bo, Zhou, Fang, Gu, Wenyi, Zhao, Liang, Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan(2010)Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes. Virology, 399 1: 46-58. doi:10.1016/j.virol.2009.12.021
  73. Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel(2009)Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 20: 8314-8319. doi:10.1073/pnas.0812085106
  74. Gu, Wenyi, Putral, Lisa and McMillan, Nigel (2008)siRNA and shRNA as anticancer agents in a cervical cancer model. Methods in Molecular Biology, 442 159-172. doi:10.1007/978-1-59745-191-8_12
  75. Gu, Wenyi, Ding, Jianmin M., Wang, Xiao, de Kluyver, Rachel L., Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2007)Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Research, 35 14: 4820-4832. doi:10.1093/nar/gkm496
  76. Fang, N. X., Gu, W., Ding, J., Saunders, N. A., Frazer, I. H. and Zhao, K. N. (2007)Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes. Virology, 365 1: 187-197. doi:10.1016/j.virol.2007.03.038
  77. Gu, W. Y., Putral, L. N., Irving, A. and McMillan, N. A. J. (2007)The development and future of oligonucleotide-based therapies for cervical cancer. Current Opinions in Molecular Therapeutics, 9 2: 126-131.
  78. Irving, A, McMillan, N and Gu, WY (2007)Future of RNAi-based therapies for human papillomavirus-associated cervical cancer. Future Virology, 2 6: 587-595. doi:10.2217/17460794.2.6.587
  79. Gu, W., Putral, L., Hengst, K., Minto, K., Saunders, N. A., Leggatt, G.and McMillan, N. A. J. (2006)Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes. Cancer Gene Therapy, 13 11: 1023-1032. doi:10.1038/sj.cgt.7700971
  80. Putral, Lisa N., Gu, Wenyi and McMillan, Nigel A. J. (2006)RNA interference for the treatment of cancer. Drug News & Perspectives, 19 6: 317-324. doi:10.1358/dnp.2006.19.6.985937
  81. Gu, Wenyi, Janssens, Peter, Holland, Michael, Seamark, Robert and Kerr, Peter (2005)Lymphocytes and MHC class II positive cells in the female rabbit reproductive tract before and after ovulation. Immunology and Cell Biology, 83 6: 596-606. doi:10.1111/j.1440-1711.2005.01375.x
  82. Zhao, Kong-Nan, Gu, WenYi, Fang, Ning Xia, Saunders, Nicholas A.and Frazer, Ian H. (2005)Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo. Molecular And Cellular Biology, 25 19: 8643-8655. doi:10.1128/MCB.25.19.8643-8655.2005
  83. Putral, L. N., Bywater, M. J., Gu, W. Y., Saunders, N. A., Gabrielli, B. G., Leggatt, G. R. and McMillan, N. A. J. (2005)RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Molecular Pharmacology, 68 5: 1311-1319. doi:10.1124/mol.105.014191
  84. Jonsson, Julie R., Gu, Wenyi, Vanags, Daina M., Bishop, G. Alex, McCaughan, Geoffrey W., Fawcett, Jonathon, Lynch, Stephen V., Balderson, Glenda A., Powell, Elizabeth E. and Clouston, Andrew D.(2004)Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection. Liver Transplantation, 103: 397-403. doi:10.1002/lt.20084
  85. Gu, Wenyi, Holland, Michael, Janssens, Peter, Seamark, Robert and Kerr, Peter (2004)Immune response in rabbit ovaries following infection of a recombinant myxoma virus expressing rabbit zona pellucida protein B. Virology, 318 2: 516-523. doi:10.1016/j.virol.2003.10.021
  86. Gu, Wenyi, Li, Mengrong, Zhao, Wei Ming, Fang, Ning Xia, Bu, Shurui, Frazer, Ian H. and Zhao, Kong-Nan (2004)tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes. Nucleic Acids Research, 32 15: 4448-4461. doi:10.1093/nar/gkh748
  87. Zhao, Kong-Nan, Tomlinson, Liz, Liu, Wen Jun, Gu, Wenyi and Frazer, Ian H. (2003)Effects of additional sequences directly downstream from the AUG on the expression of GFP gene. BBA - Biochimeca et Biophysica Acta: international journal of biochemistry and biophysics, 1630 2-3: 84-95. doi:10.1016/j.bbaexp.2003.09.010
  88. Gu, Wenyi, Holland, Michael, Janssens, Peter and Kerr, Peter (2003)Antibody response in the female rabbit reproductive tract to influenza haemagglutinin encoded by a recombinant myxoma virus. Virology, 313 1: 286-295. doi:10.1016/S0042-6822(03)00324-6
  89. Li, L., Gu, Z., Gu, W. Y., Liu, J. and Xu, Z. P. (2015).Efficient drug delivery for cancer treatment using Si02-LDH nanocomposites. In: Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015. 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference, Washington, DC, United States, (17-20). 14-17 June 2015.
  90. Gu, W. Y., Leggatt, G., Payne, E., Wilson, D., Choyce, A. and McMillan, N. A. J. (2009).RNA interference for the treatment of cervical cancers: Solving the delivery and efficacy issues. In: Abstracts: 6th Australasian Gene Therapy Society Meeting. 6th Meeting of the Australasian Gene Therapy Society, Sydney, Australia, (842-842). 29 April - 01 May 2009. doi:10.1002/jgm.1375
  91. Clouston, A., Vanags, D. M., Gu, W. Y., Powell, E. E. and Jonsson, J. R. (2003).Absence of rejection after human liver orthotopic liver transplantation (OLT) is associated with leukocyte apoptosis, increased lymphocyte activation and higher donor cell chimerism. In: Supplement: 55th Annual Meeting of the American Association for the Study of Liver Diseases. 55th Annual Meeting of the American-Association-for-the-Study-of-Liver-Disease, Boston, MA, United States, (371A-371A). 24-28 October 2003.
  92. ​Sun, Bing; Zhao, Xiaohui; Wu, Yanheng; Cao, Pei; Movahedi, Fatemeh; Liu, Jie; Wang, Jingjing; Xu, Zhi Ping; Gu, Wenyi*. Mannose-functionalized Biodegradable Nanoparticles Efficiently Deliver DNA Vaccine and Promote Anti-tumor Immunity. ACS Applied Materials & Interfaces, 2021, 13, 12, 14015–14027.