Chyden specialises in molecular and synthetic biology in bacteria and yeast.
Chyden completed his PhD at The University of Queensland where he investigated antibiotic resistance and virulence in E. coli using multidisciplinary techniques. Following this, he undertook postdoctoral training at the Institute for Molecular Bioscience, then worked on microbial diagnostics in industry. In his current role, Chyden uses molecular and synthetic biology tools to engineer microbial strains, contributing to the development of next-generation microbial cell factories.
Collaborations
Chyden has held national and international collaborations, including with Bostjan Kobe (The University of Queensland), Begoña Heras and Jason Paxman (La Trobe University), Joel Mackay (The University of Sydney), and Randy Read (University of Cambridge).
Key Publications
Chang C, Phan MD, Schembri MA. Modified Tn7 transposon vectors for controlled chromosomal gene expression. Applied and Environmental Microbiology. 2024 Oct 23;90(10):e0155624. doi: 10.1128/aem.01556-24. Epub 2024 Sep 18. PMID: 39291982; PMCID: PMC11497813.
Lian ZJ, Nhu NTK, Ravi C, Chang C, Martinez-Roman I, Phan MD, Schembri MA. Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli. Nature Communications. 2025 Dec 10;17(1):505. doi: 10.1038/s41467-025-67202-9. PMID: 41372146; PMCID: PMC12804835.
Hancock SJ, Lo AW, Ve T, Day CJ, Tan L, Mendez AA, Phan MD, Nhu NTK, Peters KM, Richards AC, Fleming BA, Chang C, Ngu DHY, Forde BM, Haselhorst T, Goh KGK, Beatson SA, Jennings MP, Mulvey MA, Kobe B, Schembri MA. Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathogens. 2022 Jun 14;18(6):e1010582. doi: 10.1371/journal.ppat.1010582. PMID: 35700218; PMCID: PMC9236248.