Development of Targeted mRNA-LNP Therapeutics for Cancer
Sin-Wei Huang is a PhD student with diverse experience in cancer drug development throughout his research journey. During his master’s training at Academia Sinica, he used LC-MS/MS to characterise the proteomics of intratumoral bacteria and engineered E. coli capable of secreting a potent iron chelator as an anti-cancer strategy. He later joined a biotechnology start-up focused on engineering multifunctional antibody therapeutics for cancer and metabolic diseases. He is currently pursuing his PhD with Dr. Cheetham at The University of Queensland, where his research focuses on developing targeted mRNA-LNP therapeutics for cancer. Specifically, he combines bispecific antibodies with mRNA-LNPs to enable tissue-specific targeting. This approach aims to increase local drug concentration while reducing hepatic and systemic toxicity, lowering dosing frequency, and improving therapeutic efficacy. Importantly, this strategy also functions as a modular mRNA-LNP delivery platform, offering a plug-and-play design by swapping one binding arm of the bispecific antibody. By integrating the strengths of both antibody targeting and mRNA therapeutics, this technology has strong potential to overcome many of their individual limitations.
Key Publications
Sin-Wei Huang, See-Khai Lim, Yao-An Yu, Wan-Ju Lien, Kurt Yun Mou. Overcoming the nutritional immunity by engineering iron scavenging bacteria for cancer therapy. eLife 2023
Yao-An Yu, Wan-Ju Lien, Wen-Ching Lin, Yi-Chung Pan, Sin-Wei Huang, Chung-Yuan Mou, Che-Ming Jack Hu, and Kurt Yun Mou. Tri-functional High-affinity Superantigen-based Multivalent Immune Cell Engager Synergizes NK and T Cell Activation for Tumor Suppression. Advanced Science, 2024
See-Khai Lim, Wen-Ching Lin, Yi-Chung Pan, Sin-Wei Huang, Yao-An Yu, Cheng-Hung Chang, Che-Ming Jack Hu,, Chung-Yuan Mou, and Kurt Yun Mou. Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy. eLife, 2026
See-Khai Lim, Wen-Ching Lin, Sin-Wei Huang, Yi-Chung Pan, Che-Wei Hu, Chung-Yuan Mou, Che-Ming Jack Hu, and Kurt Yun Mou. Bacteria colonization in tumor microenvironment creates a favorable niche for immunogenic chemotherapy. EMBO Mol Med, 2024
Kao, Chia-Yi; Pan, Yi-Chung; Hsiao, Yi-Hsiang; Lim, See-Khai; Cheng, Ting-Wei; Huang, Sin-Wei; Wu, Shania Meng-Yun; Sun, Cheng-Pu; Tao, Mi-Hua; Mou, Kurt Yun. Improvement of Gene Delivery by Minimal Bacteriophage Particles. ACS Nano 2023