Emeritus Professor Julie Campbell

Professor Julie Campbell AO, FAA
BSc (Hons) NSW, PhD Melb.

Research highlights

Professor Campbell is a cell biologist and is recognised as a world leader in the field of smooth muscle biology. She was the first researcher to discover that smooth muscle cells can exist in a spectrum of phenotypes that control the cell’s biology and response to disease stimuli. This has helped with an understanding of how atherosclerotic plaque forms and potential prevention strategies. Professor Campbell was also the first to discover cells of bone marrow origin contribute to intimal thickening in arteries subjected to injury. Professor Campbell has been developing an artificial blood vessel grown in the peritoneal cavity of the person into whom it will be grafted. The tissue is derived from the person's own mature macrophages that have undergone trans-differentiation.

Career highlights

Professor Campbell was an NHMRC Research Fellow for 30 years, including time as a SPRF, and was a member of the executive committee and council and secretary of education and public awareness of the Australian Academy of Science for eight years. In 1995, she was awarded the Wellcome Australia Medal; was later made a Fellow of the Australian Academy of Science; awarded the Centenary Medal; received a Queensland Greats Award; been made an Officer of the Order of Australia (AO); and named the Queensland Businesswoman of the Year in the public and not-for-profit section. Professor Campbell has published 228 papers in international scientific journals and has two international patents. She had given more than 65 lectures at international conferences.

Recent publications

Full list of publications available at UQ eSpace.

• Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014) Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 6: 518-526. doi:10.1038/icb.2014.19
• Dargaville, Bronwin L., Vaquette, Cedryck, Rasoul, Firas, Cooper-White, Justin J., Campbell, Julie H. and Whittaker, Andrew K. (2013) Electrospinning and crosslinking of low-molecular-weight poly(trimethylene carbonate-co-L-lactide) as an elastomeric scaffold for vascular engineering. Acta Biomaterialia, 9 6: 6885-6897. doi:10.1016/j.actbio.2013.02.009
• Nguyen, Anh T., Gomez, Delphine, Bell, Robert D., Campbell, Julie H., Clowes, Alexander W., Gabbiani, Giulio, Giachelli, Cecilia M., Parmacek, Michael S., Raines, Elaine W., Rusch, Nancy J., Speer, Mei Y., Sturek, Michael, Thyberg, Johan, Towler, Dwight A., Weiser-Evans, Mary C., Yan, Chen, Miano, Joseph M. and Owens, Gary K. (2013) Smooth muscle cell plasticity fact or fiction?. Circulation Research, 112 1: 17-22. doi:10.1161/CIRCRESAHA.112.281048
• Gu, Zi, Rolfe, Barbara E., Xu, Zhi Ping, Campbell, Julie H., Lu, G. Q. (Max) and Thomas, Anita C. (2012) Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles. Advanced Healthcare Materials, 1 5: 669-673. doi:10.1002/adhm.201200069
• Campbell, Julie H. and Campbell, Gordon R. (2012) Smooth muscle phenotypic modulation - a personal experience. Arteriosclerosis Thrombosis and Vascular Biology, 32 8: 1784-1789. doi:10.1161/ATVBAHA.111.243212
• Gu, Z., Rolfe, Barbara E., Thomas, A. C., Campbell, Julie H., Lu, G. Q. Max and Xu, Z. P. (2012). Heparin-related nanomaterials. In David E. Piyathilake and Rhong Liang (Ed.), Heparin, properties, uses and side effects (pp. 159-178) New York, United States: Nova Science.
• Dargaville, Bronwin L., Vaquette, Cedryck, Peng, Hui, Rasoul, Firas, Chua, Yu Qian, Cooper-White, Justin J., Campbell, Julie H. and Whittaker, Andrew K. (2011) Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications. Biomacromolecules, 12 11: 3856-3869. doi:10.1021/bm201291e
• Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011) Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 25: 6709-6717. doi:10.1182/blood-2011-06-359141
• Gu, Zi, Rolfe, Barbara E., Thomas, Anita C., Campbell, Julie H., Lu, G.Q. (Max) and Xu, Zhi P. (2011) Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells. Biomaterials, 32 29: 7234-7240. doi:10.1016/j.biomaterials.2011.05.083
• Zhu, Congli, Zhang, Liang, Zheng, Yong, Xu, Jing, Song, Jian, Rolfe, Barbara E. and Campbell, Julie H. (2011) Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: A novel mechanism for the "time window theory" of menopausal hormone therapy. Atherosclerosis, 215 2: 294-300. doi:10.1016/j.atherosclerosis.2010.12.025
• Rolfe, Barbara, Mooney, Jane, Zhang, Bing, Jahnke, Sani, Le, Sarah-Jane, Chau, Yu-Qian, Huang, Qiping, Wang, Hao, Campbell, Gordon and Campbell, Julie (2011). The fibrotic response to implanted biomaterials: Implications for tissue engineering. In Daniel Eberli (Ed.), Regenerative Medicine and Tissue Engineering: Cells and Biomaterials (pp. 551-568) Rijeka, Croatia: InTech Publishing.
• Gu, Zi, Rolfe, Barbara E., Xu, Zhi P., Thomas, Anita C., Campbell, Julie H. and Lu, Gao Q.M. (2010) Enhanced effects of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells. Biomaterials, 31 20: 5455-5462. doi:10.1016/j.biomaterials.2010.03.050
• Stickler, P., De Visscher, G., Mesure, L., Famaey, N., Martin, D., Campbell, J. H., Van Oosterwyck, H., Meuris, B. and Flameng, W. (2010) Cyclically stretching developing tissue in vivo enhances mechanical strength and organization of vascular grafts. Acta Biomaterialia, 6 7: 2448-2456. doi:10.1016/j.actbio.2010.01.041
• Golledge Jonathan, Cullen, Bradford, Rush, Catherine, Moran Corey S., Secomb, Emma, Wood, Frances, Daugherty, Alan, Campbell, Julie H. and Norman, Paul E. (2010) Peroxisome proliferator-activated receptor ligands reduce aortic dilatation in a mouse model of aortic aneurysm. Atherosclerosis, 210 1: 51-56. doi:10.1016/j.atherosclerosis.2009.10.027
• Le, S. J., Gongora, M., Zhang, B., Grimmond, S., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2010) Gene expression profile of the fibrotic response in the peritoneal cavity. Differentiation, 79 4-5: 232-243. doi:10.1016/j.diff.2010.03.001
• Rotmans, J. I. and Campbell, J. H. (2010). Tissue engineering for small diameter vascular graft. In Chandra P. Sharma (Ed.), Biointegration of medical implant materials : Science and design (pp. 116-146) Boca Raton, Oxford: CRC Press : Woodhead. doi:10.1533/9781845699802.1.116
• Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010) Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 1: 369-380. doi:10.2353/ajpath.2010.090545
• Corey S. Moran, Bradford Cullen, Campbell, Julie H. and Jonathan Golledge (2009) Interaction between Angiotensin II, Osteoprotegerin, and Peroxisome Proliferator-Activated Receptor-γ in Abdominal Aortic Aneurysm. Journal of Vascular Research, 46 3: 209-217. doi:10.1159/000163019
• Lutton, Cameron, Sugiyama, Sadahiro, Wullschleger, Martin E., Williams, Richard, Campbell, Julie H., Crawford, Ross and Goss, Ben (2009) Transplanted abdominal granulation tissue induced bone formation - An in vivo study in sheep. Connective Tissue Research, 50 4: 256-262. doi:10.1080/03008200902836057
• Cao, Yang, Zhang, Bing, Croll, Tristan, Rolfe, Barbara E., Campbell, Julie H., Campbell, Gordon R., Martin, Darren and Cooper-White, Justin J. (2008) Engineering tissue tubes using novel multilayered scaffolds in the rat peritoneal cavity. Journal of Biomedical Materials Research. Part A, 87A 3: 719-727. doi:10.1002/jbm.a.31781
• Gu, Zi, Thomas, Anita C., Xu, Zhi Ping, Campbell, Julie H. and Lu, Gao Qing (2008) In Vitro Sustained Release of LMWH from MgAl-layered Double Hydroxide Nanohybrids. Chemistry of Materials, 20 11: 3715-3722. doi:10.1021/cm703602t
• Cao, Y., Clark, S., Croll, T., Campbell, J. and Cooper-White, J. (2008). Tailoring surfaces and scaffolds for cell and tissue expansion - Microenvironmental control through nanomanipulation. In: Proceedings of ASTAR Biomaterials Workshop. A*STAR CCO Workshop on Biomaterials, Singapore, (). 15 December 2008.
• Cao, Yang, Clark, Sharon F., Croll, Tristan I., Tan, Guak Kim, Dinnes, Donna L., George, Peter, Brooke, Gary, Doran, Mike, Campbell, Julie H. and Cooper-White, Justin (2008). Differential in adhered cell phenotype induced by different collagen coats of multilayered-PCL scaffolds. In: Proceedings of the Australian Health and Medical Research Congress. Australian Health and Medical Research Congress 2008, Brisbane, Qld, Australia, (302-302). 16-21 November, 2008.
• Campbell, Gordon R., Geoffrey Turnbull, Xiang, Lina, Haines, Michael, Shannon Armstrong, Rolfe, Barbara E. and Campbell, Julie H. (2008) The peritoneal cavity as a bioreactor for tissue engineering visceral organs: bladder, uterus and vas deferens. Journal of Tissue Engineering and Regenerative Medicine, 2 1: 50-60. doi:10.1002/term.66
• Campbell, G. R. and Campbell, J. H. (2007) Development of tissue engineered vascular grafts. Current Pharmaceutical Biotechnology, 8 1: 43-50. doi:10.2174/138920107779941426
• Clark, Sharon F., Cao, Yang, Croll, Tristan, Jahnke, Sani, Dyne, Al, Rolfe, Barbara, Brooke, Gary, Atkinson, Kerry, Campbell, Julie and Cooper-White, Justin (2007). Surface protein regulators of rat bone marrow-derived mesenchymal stem cell morphology. In: International Society for Stem Cell Research (ISSCR) Annual Meeting, Cairns, Qld, Australia, (). 17-20 June, 2007.
• Bingley, John, Campbell, Julie, Campbell, Gordon and Walker, Philip (2007). Restenosis: Treatment options current and future. In Robert Fitridge and Matthew Thompson (Ed.), Mechanisms of Vascular Disease: A Textbook for Vascular Surgeons (pp. 191-210) New York, NY, U.S.A.: Cambridge University Press.
• Chau, Yu-Qian, Zhang, Bing, Rolfe, Barbara, Wei, Ming and Campbell, Julie (2007). Inhibition of myofibroblast differentiation by silencing transforming growth factor beta receptor. In: Annual Congress of the European Society of Gene and Cell Therapy, De Doelen, Rotterdam, The Netherlands, (1085-1085). 27-30 October, 2007.
• Hoenig, Michel R., Campbell, Gordon R. and Campbell, Julie H. (2006) Vascular grafts and the endothelium. Endothelium, 13 6: 385-401. doi:10.1080/10623320601061615
• Knoner, Gregor, Rolfe, Barbara E., Campbell, Julie H., Parkin, Simon J., Heckenberg, Norman R. and Rubinsztein-Dunlop, Halina (2006) Mechanics of cellular adhesion to artificial artery templates. Biophysical Journal, 91 8: 3085-3096. doi:10.1529/biophysj.105.076125
• Cao, Yang, Zhang, Bing, Croll, Tristan I., Rolfe, Barbara E., Campbell, Julie H., Campbell, Gordon R., Martin, Darren J. and Cooper-White, Justin J.(2006) Engineering tissue tubes using novel multilayered scaffolds in the rabbit and rat peritoneal cavity. Tissue Engineering, 12 4: 1020-1021.
• Hoenig, Michel R., Rolfe, Barbara E. and Campbell, Julie H. (2006) Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy. Atherosclerosis, 184 2: 247-254. doi:10.1016/j.atherosclerosis.2005.09.007
• Rolfe, B. E., Zhang, B., Wigan, M. P., Pearson, K., Chen, Y., Pantarat, S., Campbell, J. H., Jahnke, S, Chau, Y. and Campbell, G. R. (2006) Growth factor regulation of myofibroblast differentiation. Cytometry Part A, 69A 5: 423-424.
• Mooney, J. E., Rolfe, B. E., Zhang, B., Sester, P., Campbell, J. H. and Campbell, G. R. (2006) Monocytes/macrophages and foreign body encapsulation in the peritoneal cavity. Cytometry Part A, 69A 5: 421-421.
• Daly, C., Campbell, G. R. and Campbell, J. H. (2006). Tissue engineering. In G. Pasterkamp and D. de Kleijn (Ed.), Cardiovascular Research: New Technologies, Methods, and Applications (pp. 207-220) New York, NY, U.S.A.: Springer Science and Business Media. doi:10.1007/b101257
• Tailford, K., Jhanke, S., Stickler, P., Le, S. J., Cong, Z., Campbell, G. R. and Campbell, J. H. (2006). S18886, a selective antagonist of TP-receptors, enhances atherosclerotic plaque stability. In: Atherosclerosis Supplements. 14th Meeting of the International-Society-of-Atherosclerosis, Rome, Italy, (325-326). 18-22 June, 2006. doi:10.1016/S1567-5688(06)81299-7
• Armstrong, S. R., Campbell, G. R., Campbell, J. H. and Little, M. H. (2006). Establishment of metanephros transplantation in mice highlights contributions by both nephrectomy and pregnancy to developmental progression. In: Cytometry. Part A. Stem cells in the age of fluorescence technology: The 2005 ISAC Samuel A. Latt conference. 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Gold Coast, Queensland, (412-413). 6-9 November 2005. doi:10.1002/cyto.a.20264
• Le, S., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2006) Life and death in developing myofibroblast capsules. Cytometry Part A, 69A 5: 419-419. doi:10.1002/cyto.a.20264
• Worth, Nathalie F., Berry, Celia L., Thomas, Anita C. and Campbell, Julie H. (2005) S18886, a selective TP receptor antagonist, inhibits development of atherosclerosis in rabbits. Atherosclerosis, 183 1: 65-73. doi:10.1016/j.atherosclerosis.2005.02.034
• Daly, C., Campbell, G. R., Walker, P. J. and Campbell, J. H. (2005) Vascular engineering for bypass surgery. Expert Review in Cardiovascular Therapy, 3 4: 659-665. doi:10.1586/14779072.3.4.659
• Hoenig, Michel R., Campbell, Gordon R., Rolfe, Barbara E. and Campbell, Julie H. (2005) Tissue-engineered blood vessels: Alternative to autologous grafts?. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 6: 1128-1134. doi:10.1161/01.ATV.0000158996.03867.72
• Campbell, J. H. (2005). Cell replication, technologies and techniques. In D. Meagher and S. Creasy (Ed.), Heinemann Biology 1 4 ed. (pp. 81-81)Australia: Heinemann Mal Parsons.
• Campbell, J. H., Efendy, J., Chue, W., Daly, C., Mooney, J., Zhang, B., Rolfe, B., Walker, P. and Campbell, G. R. (2005). Artifical arteries from cells of bone marrow origin. In: Past, Present and Future: The Evolution of the Vascular Specialist. Vascular 2005, Sydney, (70-70). 9-14 Sep, 2005.
• Golledge, J. and Campbell, J. H. (2005) Local therapy for restenosis. European Journal of Vascular And Endovascular Surgery, 30 6: 571-572. doi:10.1016/j.ejvs.2005.08.002
• Rolfe, B. E., Worth, N. F., World, C. J., Campbell, J. H. and Campbell, G. R. (2005) Rho and vascular disease. Atherosclerosis, 183 1: 1-16. doi:10.1016/j.atherosclerosis.2005.04.023
• Armstrong, S. R., Campbell, G. R., Campbell, J. H. and Little, M. H. (2005) Establishment of metanephros transplantation in mice highlights contributions by both nephrectomy and pregnancy to developmental progression. Nephron Experimental Nephrology, 101 4: E155-E164. doi:10.1159/000087939
• Worth, N. F., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2004) Rho expression and activation in vascular smooth muscle cells. Cell Motility and the Cytoskeleton, 59 3: 189-200. doi:10.1002/cm.20036
• Daly,Chris D., Campbell, Gordon R., Walker, Philip J. and Campbell, Julie H. (2004) In vivo engineering of blood vessels. Frontiers In Bioscience, 9 2: 1915-1924. doi:10.2741/1384
• Chue, W.L., Campbell, G. R., Caplice, N., Muhammed, A., Berry, C. L., Thomas, A. C., Bennett, M. B. and Campbell, J. H. (2004) Dog peritoneal and pleural cavities as bioreactors to grow autologous vascular grafts. Journal of Vascular Surgery, 39 4: 859-867. doi:10.1016/j.jvs.2003.03.003
• World, C.J., Merrilees, M.J., Beaumont, B., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2004) The effects of leukemia inhibitory factor (LIF) on neointimal formation in injured arteries. Biomedical Research, 15 2: 169-175.