Multifunctional Layered Double Hydroxide Nanoparticles for Cancer Therapy

The complexity and diversity of tumors pose considerable challenges in the search for desirable therapeutics. One of the current focuses in clinical anticancer investigations is to shift from monotherapy to combination therapy, which aims to achieve enhanced efficacy under synergistic interactions among individual therapeutic modalities. Moreover, many versatile medical imaging techniques utilizing fluorescence, ultrasound, or magnetic resonance imaging (MRI) have enabled the early diagnosis of cancer and accurate location of tumors. There is a pressing demand to develop novel theranostic platforms, which can realize combination therapy under the synergism of multitherapeutics and allow precise tumor detection and treatment under cooperative imaging guidance. Luyao Sun is focusing on developing layered double hydroxide nanoparticles as a nanoplateform to treat cancer.

​2018.10- present: Ph.D. candidate at The University of Queensland, under the supervision of Prof. Zhi Ping (Gordon) Xu; 

2018.4- 2018.9: Research Assistant in SouthernUniversity of Science and Technology, under the supervision of Prof. Qiongyu Guo; 

2015.9- 2018.4: M.S. in South China University of Technology, under the supervision of Prof. Xiaofeng Chen; 

2011.9- 2015.7: B.S. in Wuhan University of Technology, under the supervision of Prof. Yu Li

Awards: UQ Research Training Scholarship

Patents: CN201610816437.1, CN201711239072.1, CN201710620309.4, CN201711352713.4

Industry

​Luyao Sun worked in Foshan Jinlan Biotechnology Co. Ltd from 2016 to 2018, participated in research and production of products, responsible for the quality control, inspection and standard establishment in the product declaration.

Collaborations

Luyao Sun collaborated with Guangdong Pharmaceutical University in animal experiment from 2016 to 2018. 

Key Publications

  1. Luyao Sun, Wendong Gao, Xiaoling Fu, et al., Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the basketweave pattern of collagen fibrils in native skin, Biomater. Sci. 2018, 6, 340-349.
  2. Wendong Gao, Luyao Sun, Xiaoling Fu, et al., Enhanced diabetic wound healing by electrospun core-sheath fibers loaded with dimethyloxalylglycine, J. Mater. Chem. B 2018, 6, 277-288.
  3. Mingyu He, Luyao Sun, Xiaoling Fu, et al., Biodegradable amino acid-based poly(ester amine) with tunable immunomodulating properties and their in vitro and in vivo wound healing studies in diabetic rats' wounds. Acta Biomater. 2019, 84, 114-132.
  4. Wen Zhang, Deqiu Huang, Fujian Zhao, Wendong Gao, Luyao Sun, et al., Synergistic effect of strontium and silicon in strontium-substituted sub-micron bioactive glass for enhanced osteogenesis, Mater. Sci. Eng. C. 2018, 89, 245-255.