Using RNAi to treat viral diseases and cancers; immunology and vaccine development

Dr. Wenyi Gu’s early education was conducted in China which include his undergraduate and master’s degrees in veterinary medicine. In 1996, he migrated to Australia and pursued his PhD study in biochemistry & molecular biology at the Australian National University (ANU). After a short period of work at John Curtin Medical School ANU as a junior scientist, he moved to Brisbane in 2001 for his post-doc at the University of Queensland and currently a post-doctoral research fellow at AIBN. He held a Peter Doherty Fellowship (2006-2009) and was further supported by NHMRC to spend 7 months at Harvard University as a visiting fellow in 2008. Since his post-doctoral research he has been working in the area of using RNAi to treat viral diseases and cancers. He also has a strong background in immunology and vaccine development.

Key Publications

  1. Gu, Wenyi, McMillan, Nigel and Yu, Chengzhong (2015).Silencing of E6/E7 expression in cervical cancer stem-like cells. In Daniel Keppler and Athena W. Lin (Ed.), Cervical cancer: methods and protocols (pp. 173-182) New York, NY United States: Springer. doi:10.1007/978-1-4939-2013-6_12
  2. Zhou, YinghongChakravorty, NishantXiao, Yin and Gu, Wenyi(2013).Mesenchymal stem cells and nano-structured surfaces. In Turksen, K (Ed.), Stem Cell Nanotechnology: Methods and Protocols(pp. 133-148) New York, NY, United States: Humana Press. doi:10.1007/7651_2013_30
  3. Gu, W.Putral, L. and McMillan, N. A. J. (2008).siRNA and shRNA as anti-cancer agents in a cervical cancer model. In J. M. Walker (Ed.), RNAi : design and application(pp. 159-172) Totowa, N.J., U.S.A.: Humana Press, Inc..
  4. Zheng, YangWang, ZhaoXiong, XianbinZhong, YiZhang, WeiDong, YiboLi, JialiangZhu, ZaiouZhang, WeiWu, HemingGu, Wenyi, Wu, YunongWang, Xiang and Song, Xiaomeng (2019)Membrane-tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinomaJournal of Cellular Physiology234 5: 5940-5952. doi:10.1002/jcp.27022
  5. Gu, Wenyi, Sun, SurongKahn, AndrewDacus, DaltonWendel, Sebastian O.McMillan, Nigel and Wallace, Nicholas A. (2019)Cervical cancer cell lines are sensitive to sub-erythemal UV exposureGene688 44-53. doi:10.1016/j.gene.2018.11.079
  6. Chen, MingshuiSharma, AditiLin, YanlingWu, YanhengHe, QiGu, YushuXu, Zhi PingMonteiro, Michael and Gu, Wenyi (2019)Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cellsBMC Cancer19 1: 153. doi:10.1186/s12885-019-5364-3
  7. Gu, Wenyi, Wang, LihuiWu, Yanheng and Liu, Jun-Ping (2019)Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cellsClinical and Experimental Pharmacology and Physiology462: 105-115. doi:10.1111/1440-1681.13056
  8. Li, MengxueSultanbawa, YasminaXu, Zhi PingGu, Wenyi, Chen, WeiyuLiu, Jianyong and Qian, Guangren (2019)High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxideColloids and Surfaces B: Biointerfaces174 435-442. doi:10.1016/j.colsurfb.2018.11.035
  9. Wu, Yanheng, Gu, WenyiLi, LiChen, Chen and Xu, Zhi (2019)Enhancing PD-1 gene silence in T lymphocytes by comparing the delivery performance of two inorganic nanoparticle platformsNanomaterials9 2: 159. doi:10.3390/nano9020159
  10. Wu, Yilun, Gu, Wenyi and Xu, Zhi Ping (2019)Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platformNanomedicine14 1: 77-92. doi:10.2217/nnm-2018-0252
  11. Tao, LinAmanguli, A.Li, FengWang, Ying HongYang, LanMohemaiti, MeiliguliZhao, JinZou, Xiao GuangSaimaiti, AbudukeyoumuAbudu, MirenshaMaimaiti, MikairemuChen, Shi YanAbudukelimu, RuxianguliMaimaiti, AyinuerLi, Shu GangZhang, WeiAizimu, AyinuerYang, An QiangWang, JuPang, Li JuanCao, Yu Guang, Gu, Wen Yi and Zhang, Wen Jie (2018)Cervical Screening by Pap Test and Visual Inspection Enabling Same-Day Biopsy in Low-Resource, High-Risk CommunitiesObstetrics and gynecology132 6: 1421-1429. doi:10.1097/AOG.0000000000002973
  12. Yan, ShiyuXu, KeweiLi, LiGu, Wenyi, Rolfe, Barbara E. and Xu, Zhi P. (2018)The pathways for layered double hydroxide nanoparticles to enhance antigen (cross)-presentation on immune cells as adjuvants for protein vaccinesFrontiers in Pharmacology91060. doi:10.3389/fphar.2018.01060
  13. Gu, Wenyi, Bobrin, Valentin A.Chen, Sung-Po R.Wang, ZhaoSchoning, Jennifer P.Gu, YushuChen, WeiyuChen, MingshuiJia, Zhongfan and Monteiro, Michael J. (2018)Biodistribution of PNIPAM-Coated Nanostructures Synthesized by the TDMT MethodBiomacromolecules, . doi:10.1021/acs.biomac.8b01196
  14. Wu, YanhengGu, WenyiChen, ChenDo, Son Trong and Xu, Zhi Ping (2018)Optimization of formulations consisting of layered double hydroxide nanoparticles and small interfering RNA for efficient knockdown of the target geneACS Omega3 5: 4871-4877. doi:10.1021/acsomega.8b00397
  15. Wang, Jie, Gu, Wenyi and Chen, Chen (2018)Knocking down insulin receptor in pancreatic beta cell lines with lentiviral-small hairpin RNA reduces glucose-stimulated insulin secretion via decreasing the gene expression of insulin, GLUT2 and Pdx1International Journal of Molecular Sciences19 4: 985. doi:10.3390/ijms19040985
  16. Wang, NingLiu, Zi-HanZou, HongPang, Li-Juan, Gu, Wen-Yi, Hu, Jian-MingLi, Dong-MeiZhao, JinZhang, JunLiu, Chun-XiaZhang, Wen-JieQi, Yan and Li, Feng (2018)Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcomaClinical and Experimental Pharmacology & Physiology45 7: 675-682. doi:10.1111/1440-1681.12936
  17. Zheng, YangWang, ZhaoDing, XuZhang, WeiLi, GangLiu, LaikuiWu, Heming, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2018)A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinomaCancer Cell International18 1: 1-15. doi:10.1186/s12935-017-0496-5
  18. Liu, TingtingLiu, Lihong, Gu, WenyiLiu, Jian and Liu, Shaomin(2018)One-pot synthesis of raspberry-like mesoporous silica nanospheresJournal of Nanoscience and Nanotechnology18 1: 401-406. doi:10.1166/jnn.2018.14607
  19. Li, KeluMa, HongmeiZheng, XiuyanHu, YaliWang, YueZhang, KunpengChen, JiahanQi, YanJiang, JinfangPang, LijuanTao, Lin, Gu, Wenyi, Li, Feng and Zou, Hong (2018)Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progressionInternational Journal of Clinical and Experimental Pathology11 3: 1707-1711.
  20. Zheng, YangWang, ZhaoDing, XuDong, YiboZhang, WeiZhang, WeiZhong, Yi, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2017)Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinomaCell Proliferation51 3: e12424. doi:10.1111/cpr.12424
  21. Yan, ShiyuGu, WenyiZhang, BingRolfe, Barbara E and Xu, Zhi Ping (2017)High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulationsDalton Transactions47 9: 2956-2964. doi:10.1039/c7dt03725b
  22. Movahedi, FatemehLi, LiGu, Wenyi and Xu, Zhi Ping (2017)Nanoformulations of albendazole as effective anticancer and antiparasite agentsNanomedicine12 20: 2555-2574. doi:10.2217/nnm-2017-0102
  23. Wu, Yilun, Gu, Wenyi, Tang, Jie and Xu, Zhi Ping (2017)Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene deliveryJournal of Materials Chemistry B534: 7194-7203. doi:10.1039/c7tb01635b
  24. Qi, YanWang, NingHe, YonglaiZhang, JunZou, HongZhang, Wenjie, Gu, WenyiHuang, YalanLian, XiaojuanHu, JianmingZhao, JinCui, XiaobinPang, Lijuan and Li, Feng (2017)Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cellsPLoS One12 8: e0182680. doi:10.1371/journal.pone.0182680
  25. Liu, HangruiSong, FanGu, WenyiFeng, JinianCai, Wanzhi and Shao, Renfu (2017)Novel insights into mitochondrial gene rearrangement in thrips (Insecta: Thysanoptera) from the grass thrips, Anaphothrips obscurusScientific Reports7 1: 4284. doi:10.1038/s41598-017-04617-5
  26. Li, LiZhang, RunGu, Wenyi and Ping, Zhi (2017)Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapyNanomedicine: Nanotechnology, Biology and Medicine14 7: 2355-2364. doi:10.1016/j.nano.2017.06.006
  27. Wu, YanhengChen, MingshuiWu, PeihongChen, ChenXu, Zhi Ping and Gu, Wenyi (2017)Increased PD-L1 expression in breast and colon cancer stem cellsClinical and Experimental Pharmacology and Physiology44 5: 602-604. doi:10.1111/1440-1681.12732
  28. Qi, YanHuang, YalanPang, LijuanGu, WenyiWang, NingHu, JianmingCui, XiaobinZhang, JunZhao, JinLiu, ChunxiaZhang, WenjieZou, Hong and Li, Feng (2017)Prognostic value of the MicroRNA-29 family in multiple human cancers: a meta-analysis and systematic reviewClinical and Experimental Pharmacology and Physiology44 4: 441-454. doi:10.1111/1440-1681.12726
  29. Schoning, Jennifer PetraMonteiro, Michael and Gu, Wenyi (2017)Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2αClinical and Experimental Pharmacology & Physiology44 2: 153-161. doi:10.1111/1440-1681.12693
  30. Singhania, RichaPavey, SandraPayne, ElizabethGu, Wenyi, Clancy, JenniferJubair, LuqmanPreiss, ThomasSaunders, Nicholas and McMillan, Nigel A. J. (2016)Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediatesBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms1859 8: 1034-1042. doi:10.1016/j.bbagrm.2016.06.005
  31. Prasadam, IndiraBatra, JyotsnaPerry, SamuelGu, Wenyi, Crawford, Ross and Xiao, Yin (2016)Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesisCalcified Tissue International99 1: 43-55. doi:10.1007/s00223-016-0125-7
  32. Li, LiGu, Zi, Gu, WenyiLiu, Jian and Xu, Zhi Ping (2016)Efficient drug delivery using SiO2-layered double hydroxide nanocompositesJournal of Colloid and Interface Science47047-55. doi:10.1016/j.jcis.2016.02.042
  33. Zou, HongLi, LiGarcia Carcedo, InesXu, Zhi PingMonteiro, Michael and Gu, Wenyi (2016)Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/ mTOR dual inhibitor BEZ235 through apoptosisInternational Journal of Nanomedicine11 1947-1958. doi:10.2147/IJN.S100744
  34. Chen, WeiyuZhang, BingMahony, TimothyGu, WenyiRolfe, Barbara and Xu, Zhi Ping (2016)Efficient and durable vaccine against Intimin β of Diarrheagenic E. Coli induced by clay nanoparticlesSmall12 12: 1627-1639. doi:10.1002/smll.201503359
  35. Li, L.Gu, Z., Gu, W. Y. and Xu, Z. P. (2016)Direct synthesis of layered double hydroxide nanosheets for efficient siRNA deliveryRSC Advances6 98: 95518-95526. doi:10.1039/c6ra19225d
  36. Yu, MeihuaNiu, YutingZhang, JunZhang, HongweiYang, YannanTaran, ElenaJambhrunkar, Siddharth, Gu, WenyiThorn, Peter and Yu, Chengzhong (2015)Size-dependent gene delivery of amine-modified silica nanoparticlesNano Research9 2: 291-305. doi:10.1007/s12274-015-0909-5
  37. Chen, JiezhongShao, RenfuLi, FengMonteiro, MichaelLiu, Jun-PingXu, Zhi Ping and Gu, Wenyi (2015)PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cellsClinical and Experimental Pharmacology and Physiology42 12: 1317-1326. doi:10.1111/1440-1681.12493
  38. Gu, Wenyi, Prasadam, IndiraYu, MeihuaZhang, FengxiaLing, PatrickXiao, Yin and Yu, Chengzhong (2015)Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathwayBMC Cancer15 1: 1-11. doi:10.1186/s12885-015-1614-1
  39. Chen, JiezhongGu, Wenyi, Yang, LeiChen, ChenShao, RenfuXu, Kewei and Xu, Zhi Ping (2015)Nanotechnology in the management of cervical cancerReviews in Medical Virology25 S1: 72-83. doi:10.1002/rmv.1825
  40. Li, LiGu, Wenyi, Liu, JianYan, Shiyu and Xu, Zhi Ping (2015)Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene deliveryNano Research8 2: 682-694. doi:10.1007/s12274-014-0552-6
  41. Yan, ShiyuRolfe, Barbara E.Zhang, BingMohammed, Yousuf H.Gu, Wenyi and Xu, Zhi P. (2014)Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpGBiomaterials35 35: 9508-9516. doi:10.1016/j.biomaterials.2014.07.055
  42. Chen, JiezhongShao, RenfuLi, LiXu, Zhi Ping and Gu, Wenyi(2014)Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathwaysInternational Journal of Nanomedicine9 1: 3403-3411. doi:10.2147/IJN.S61633
  43. Pan, Q. F.Li, W. T.Dong, H. C.Chen, Y. Z.Yin, L.Liu, W.Wang, W. W.Liu, D.Li, S. G., Gu, W. Y.Chen, J. Z.Yang, L.Zhang, W. J. and Li, F. (2014)PTEN hypermethylation profiles of Chinese Kazakh patients with esophageal squamous cell carcinomaDiseases of the Esophagus27 4: 396-402. doi:10.1111/dote.12106
  44. Tan, XiaohuaYang, LiXian, LinglingHuang, JinDi, ChunhongGu, Wenyi, Guo, Shuli and Yang, Lei (2014)ATP- binding cassette transporter A1 ( ABCA1) promotes arsenic tolerance in human cells by reducing cellular arsenic accumulationClinical and Experimental Pharmacology and Physiology41 4: 287-294. doi:10.1111/1440-1681.12219
  45. Li, Li, Gu, WenyiChen, JiezhongChen, Weiyu and Xu, Zhi P. (2014)Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticlesBiomaterials35 10: 3331-3339. doi:10.1016/j.biomaterials.2013.12.095
  46. Cui, XiaobinZhao, ZhiminLiu, DongGuo, TaoLi, SuHu, JianmingLiu, ChunxiaYang, LanCao, YuwenJiang, JinfangLiang, WeihuaLiu, WeiLi, ShugangWang, LianghaiWang, LidongGu, Wenyi, Wu, ChuanyueChen, Yunzhao and Li, Feng (2014)Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinomaJournal of Experimental and Clinical Cancer Research33 1: . doi:10.1186/1756-9966-33-20
  47. Hartono, Sandy B.Yu, MeihuaGu, Wenyi, Yang, JieStrounina, EkaterinaWang, XiaolinQiao, Shizhang and Yu, Chengzhong(2014)Synthesis of multi-functional large pore mesoporous silica nanoparticles as gene carriersNanotechnology25 5: 055701.1-055701.13. doi:10.1088/0957-4484/25/5/055701
  48. Chen, ZetaoWu, ChengtieGu, Wenyi, Klein, TravisCrawford, Rossand Xiao, Yin (2014)Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathwayBiomaterials35 5: 1507-1518. doi:10.1016/j.biomaterials.2013.11.014
  49. Niu, YutingYu, MeihuaHartono, Sandy B.Yang, JieXu, HongyiZhang, HongweiZou, JunZou, JinDexter, AnnetteGu, Wenyi and Yu, Chengzhong (2013)Nanoparticles mimicking viral surface topography for enhanced cellular deliveryAdvanced Materials25 43: 6233-6237. doi:10.1002/adma.201302737
  50. Cui, Xiao-BinChen, Yun-ZhaoPang, Xue-lianLiu, WeiHu, Jian-MingLi, Shu-GangYang, LanZhang, Wen-JieLiu, Chun-xiaCao, Yu-wenJiang, Jin-Fang, Gu, Wen-Yi, Pang, JamesYang, LeiYuan, Xiang-LinYu, Shi-Ying and Li, Feng (2013)Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh populationGene530 2: 315-322. doi:10.1016/j.gene.2013.08.057
  51. Prasadam, IndiraFarnaghi, SabaFeng, Jian Q.Gu, Wenyi, Perry, SamuelCrawford, Ross and Xiao, Yin (2013)Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: Role of integrinβ1 and focal adhesion kinase signaling cuesArthritis Research & Therapy15 5: . doi:10.1186/ar4333
  52. Chen, Yun-ZhaoCui, Xiao-BinHu, Jian-MingZhang, Wen JieLi, Shu-GangYang, LanShen, Xi-HuaLiu, Chun-XiaPan, Qing-FangYu, Shi-YingYuan, Xiang-LinYang, LeiGu, Wen-YiChen, Jie-ZhongWang, Li-Dong and Li, Feng (2013)Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressivenessApmis121 10: 908-918. doi:10.1111/apm.12095
  53. Gu, Wenyi, Jia, ZhongfanTruong, Nghia P.Prasadam, IndiraXiao, Yin and Monteiro, Michael J. (2013)Polymer nanocarrier system for endosome escape and timed release of siRNA with complete gene silencing and cell death in cancer cellsBiomacromolecules14 10: 3386-3389. doi:10.1021/bm401139e
  54. Truong, Nghia P., Gu, WenyiPrasadam, IndiraJia, ZhongfanCrawford, RossXiao, Yin and Monteiro, Michael J. (2013)An influenza virus-inspired polymer system for the timed release of siRNANature Communications4 1: . doi:10.1038/ncomms2905
  55. Yan, Shiyu, Gu, Wenyi and Xu, Zhi Ping (2013)Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responsesJournal of Colloid and Interface Science395 1: 1-10. doi:10.1016/j.jcis.2012.11.061
  56. Tang, TaoWong, Hoi Kin, Gu, Wenyi, Yu, Mei-yungTo, Ka-FaiWang, Chi ChiuWong, Yick FuCheung, Tak HongChung, Tony Kwok Hung and Choy, Kwong Wai (2013)MicroRNA-182 plays an onco-miRNA role in cervical cancerGynecologic Oncology129 1: 199-208. doi:10.1016/j.ygyno.2012.12.043
  57. Nguyen, Tran T. D.Nghia, Truong P., Gu, Wenyi, Jia, ZhongfanCooper, Matthew A. and Monteiro, Michael J. (2013)Timed-release polymer nanoparticlesBiomacromolecules142: 495-502. doi:10.1021/bm301721k
  58. Gu, WenyiChen, Chen and Zhao, Kong-Nan (2013)Obesity-associated endometrial and cervical cancersFrontiers in Bioscience5 1: 109-118.
  59. Gu, WenyiWu, ChengtieChen, Jiezhong and Xiao, Yin (2013)Nanotechnology in the targeted drug delivery for bone diseases and bone regenerationInternational Journal of Nanomedicine8 2305-2317. doi:10.2147/IJN.S44393
  60. Yu, MeihuaJambhrunkar, SiddharthThorn, PeterChen, JiezhongGu, Wenyi and Yu, Chengzhong (2013)Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cellsNanoscale5 1: 178-183. doi:10.1039/c2nr32145a
  61. Qian, KunLiu, FangYang, JieHuang, Xiaodan, Gu, WenyiJambhrunkar, SiddharthYuan, Pei and Yu, Chengzhong (2013)Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymersRSC Advances334: 14466-14472. doi:10.1039/c3ra41332b
  62. Niu, YutingPopat, AmiraliYu, MeihuaKarmakar, Surajit, Gu, Wenyiand Yu, Chengzhong (2012)Recent advance in silica-based engineered nanoparticles for gene therapyTherapeutic Delivery3 10: 1217-1237. doi:10.4155/tde.12.98
  63. Yu, MeihuaZhou, LiangZhang, JunYuan, PeiThorn, Peter, Gu, Wenyi and Yu, Chengzhong (2012)A simple approach to prepare monodisperse mesoporous silica nanospheres with adjustable sizesJournal of Colloid and Interface Science376 1: 67-75. doi:10.1016/j.jcis.2012.03.014
  64. Hartono, Sandy B., Gu, WenyiKleitz, FreddyLiu, JianHe, LizhongMiddelberg, Anton P. J.Yu, ChengzhongLu, Gao Qing (Max) and Qiao, Shi Zhang (2012)Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene deliveryACS Nano6 3: 2104-2117. doi:10.1021/nn2039643
  65. Qian, Kun, Gu, WenyiYuan, PeiLiu, FangWang, YunhuaMonteiro, Michael and Yu, Chengzhong (2012)Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheresSmall8 2: 231-236. doi:10.1002/smll.201101770
  66. Gislette, TiphaineZhao, Kong-Nan, Gu, Wenyi and Chen, Jiezhong(2012)The possible mechanisms for β-glucans to prevent atherosclerotic lesionsCurrent Bioactive Compounds8 2: 146-150. doi:10.2174/157340712801784796
  67. Gu, Wenyi, Chen, JeizhongYang, Lei and Zhao, Kong-Nan (2012)TNF-alpha promotes IFN-gamma-induced CD40 expression and antigen process in Myb-transformed hematological cellsThe Scientific World Journal2012 621969.1-621969.11. doi:10.1100/2012/621969
  68. Gu, W.Yeo, E.McMillan, N. and Yu, C. (2011)Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal abilityCancer Gene Therapy18 12: 897-905. doi:10.1038/cgt.2011.58
  69. Chen, Jiezhong, Gu, Wenyi and Zhao, Kongnan (2011)The role of PI3K/Akt pathway in beta-glucan-induced dendritic cell maturationInternational Immunopharmacology11 4: 529-529. doi:10.1016/j.intimp.2011.01.027
  70. Gu, Wenyi, An, JiyuanYe, PingZhao, KongNan and Antonsson, Annika (2011)Prediction of conserved microRNAs from skin and mucosal human papillomavirusesArchives of Virology156 7: 1161-1171. doi:10.1007/s00705-011-0974-3
  71. Gu, WenyiPayne, ElizabethSun, SurongBurgess, Melinda and McMillan, Nigel A. J. (2011)Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAsCancer Gene Therapy18 3: 219-227. doi:10.1038/cgt.2010.72
  72. Ding, JianminDoorbar, JohnLi, BoZhou, Fang, Gu, WenyiZhao, LiangSaunders, Nicholas A.Frazer, Ian H. and Zhao, Kong-Nan(2010)Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytesVirology399 1: 46-58. doi:10.1016/j.virol.2009.12.021
  73. Gu, WenyiCochrane, MelanieLeggatt, GrahamPayne, ElizabethChoyce, AllisonZhou, FangTindle, Robert and McMillan, Nigel(2009)Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responsesProceedings of the National Academy of Sciences of the United States of America106 20: 8314-8319. doi:10.1073/pnas.0812085106
  74. Gu, WenyiPutral, Lisa and McMillan, Nigel (2008)siRNA and shRNA as anticancer agents in a cervical cancer modelMethods in Molecular Biology442 159-172. doi:10.1007/978-1-59745-191-8_12
  75. Gu, WenyiDing, Jianmin M.Wang, Xiaode Kluyver, Rachel L.Saunders, Nicholas A.Frazer, Ian H. and Zhao, Kong-Nan (2007)Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiationNucleic Acids Research35 14: 4820-4832. doi:10.1093/nar/gkm496
  76. Fang, N. X.Gu, W.Ding, J.Saunders, N. A.Frazer, I. H. and Zhao, K. N. (2007)Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genesVirology365 1: 187-197. doi:10.1016/j.virol.2007.03.038
  77. Gu, W. Y.Putral, L. N.Irving, A. and McMillan, N. A. J. (2007)The development and future of oligonucleotide-based therapies for cervical cancerCurrent Opinions in Molecular Therapeutics9 2: 126-131.
  78. Irving, AMcMillan, N and Gu, WY (2007)Future of RNAi-based therapies for human papillomavirus-associated cervical cancerFuture Virology2 6: 587-595. doi:10.2217/17460794.2.6.587
  79. Gu, W.Putral, L.Hengst, K.Minto, K.Saunders, N. A.Leggatt, G.and McMillan, N. A. J. (2006)Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenesCancer Gene Therapy13 11: 1023-1032. doi:10.1038/sj.cgt.7700971
  80. Putral, Lisa N., Gu, Wenyi and McMillan, Nigel A. J. (2006)RNA interference for the treatment of cancerDrug News & Perspectives19 6: 317-324. doi:10.1358/dnp.2006.19.6.985937
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