Ramanathan Yegappan researches the Development of Procoagulant-Based Rapid Wound Sealant
Current research focusses on developing an efficacious wound dressing material based on hydrogel scaffold that brings about rapid blood clotting with the incorporation of Procoagulant Snake Venom Protein (PSVP) originally isolated from snake venom in combination with an agent to stop blood clot breakdown.
Ramanathan Yegappan completed his Bachelor of Technology (B.Tech) in Genetic Engineering from SRM Institute of Science and Technology, India in 2015 and completed his Bachelors dissertation in Texas A&M University, US where he developed hydrogel microparticles via sequential click reactions. He was a visiting international research student in University of South Australia, Adelaide in 2015-2016 where he studied the kinetics of Diels-Alder click reactions for bioconjugation. His passion to understand material interface with biology at nano- scale motivated him to complete his Master of Technology (M.Tech) in Nanomedical Sciences from Amrita Centre for Nanosciences and Molecular Medicine, India in 2018. During his period, he was a recipient of scholarship funded by Nanomission, Department of Science and Technology, Government of India under the M.Tech program. He was also a part of various research projects related to synthesis of ceramic and polymeric nanoparticles in combination with hydrogels for bone tisse engineerning and wound healing. In 2019, he started his PhD in Australian Institute for Bioengineering and Nanotechnology at the University of Queensland under the supervision of Prof. Alan Rowan, Dr. Amanda Kijas and Dr. Jan Lauko.
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Key Publications
Ramanathan Yegappan, Vignesh Selvaprithiviraj, Annapoorna Mohandas, R. Jayakumar. Nano-Polydopamine crosslinked thiol functionalized hyaluronic acid hydrogel for angiogenic drug delivery. Colloids and Surfaces B: Biointerfaces, 2019, 177, 41-49.
Muthuswamy Shiva*, Viswanathan Aparna*, Ramanathan Yegappan*, Vignesh Selvaprithiviraj, Anil Kumar Vasudevan, Raja Biswas, R. Jayakumar. Anti-staphylococcal and neutrophil chemotactic injectable κ-carrageenan hydrogel for infectious wound healing. ACS Applied Biomaterials, 2019, 2 (1), 378-387. * denotes equal contribution by authors.
Ramanathan Yegappan, Vignesh Selvaprithiviraj, Sivashanmugam Amirthalingam, Annapoorna Mohandas, Nathaniel S. Hwang, R. Jayakumar. Injectable angiogenic and osteogenic carrageenan nanocomposite hydrogel for bone tissue engineering. International Journal of Biological Macromolecules, 2019, 122, 320-328.
Ramanathan Yegappan, Vignesh Selvaprithiviraj, Sivashanmugam Amirthalingam, and R. Jayakumar. Carrageenan based Hydrogels for Drug Delivery, Tissue Engineering and Wound healing applications. Carbohydrate Polymers, 2018, 198, 385-400.
Faraz Jivan*, Ramanathan Yegappan*, Hannah Pearce, James K. Carrow, Michael McShane, Akhilesh K. Gaharwar, and Daniel L. Alge. Sequential Thiol-Ene and Tetrazine Click Reactions for the Polymerization and Functionalization of Hydrogel Microparticles. ACS Biomacromolecules, 2016, 17(11), 3516-3523. * denotes equal contribution by authors.