Craig specializes in bioprocess modelling and systems biology analytics.
Craig's research integrates various forms of 'omics data to understand and improve biological expression systems in the context of industrial biotechnology. The phenotypes of cell expression systems, whether microbial or mammalian, are defined by the complex network of biochemical reactions that happen in the cell. Our ability to characterise these phenotypes by measuring snapshots of the metabolome, transcriptome, and proteome allows us to put these phenotypes in context and understand what makes them tick. Craig uses cutting edge and novel methods for the collection and analysis of multi-omics data, particularly proteomics data, to assess and direct the optimisation of industrial bioprocesses and cell expression systems. Dr Barry attained a BE (Chemical) and BBiotech (Bioprocess) at the University of Queensland. He undertook his PhD with the ARC Training Center for Biopharmaceutical Innovation under the supervision of Prof Esteban Marcellin at the Australian Insitute for Bioengineering and Nanotechnology (AIBN). During his PhD he worked on projects with Patheon by Thermo Fisher and CSL concerning the unique challenges of mammalian bioprocesses modelling and optimisation. Craig is currently a Postdoctoral researcher at the ARC Center of Excellence in Synthetic Biology in Prof Lars Nielsen's group at AIBN.
Collaborations
Currently, Craig collaborates with the Australian Redcross Lifeblood to characterise the unique cell phenotypes which occur during the process red blood cell production.
Key Publications
MacDonald MA, Barry C, Groves T, Martínez VS, Gray PP, Baker K, Shave E, Mahler S, Munro T, Marcellin E, Nielsen LK. Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok. Biotechnol Bioeng. 2022 Jun;119(6):1380-1391. doi: 10.1002/bit.28062. Epub 2022 Mar 6. PMID: 35180317; PMCID: PMC9310834.
Barry CP, Gillane R, Talbo GH, Plan M, Palfreyman R, Haber-Stuk AK, Power J, Nielsen LK, Marcellin E. “Multi-omic characterisation of Streptomyces hygroscopicus NRRL 30439: detailed assessment of its secondary metabolic potential.” Molecular Omics. 2022 Mar 28;18(3):226-236. doi: 10.1039/d1mo00150g. PMID: 34989730.