Dr. Dalila Iannotta has experience leading various projects focused on nanomedicine for diagnostic and therapeutic purposes.

Her professional goal is to contribute to society by developing new drug delivery systems for various diseases, such as cardiovascular disease. She has experience designing and synthesizing synthetic nanoparticles, such as liposomes. Additionally, she is an expert in biological nanoparticles, primarily extracellular vesicles.
She uses various sources, such as cell culture media and plasma, to obtain extracellular vesicles and assess their potential as drug delivery systems. In particular, she is focusing on developing hybrid strategies that combine synthetic and biological nanoparticles to overcome challenges and combine advantages of each approach.

Key publications

  1. Amruta A, Iannotta D, Cheetham SW, Lammers T, Wolfram J. Vasculature organotropism in drug delivery [published online ahead of print, 2023 Aug 15]. Adv Drug Deliv Rev. 2023;201:115054. doi:10.1016/j.addr.2023.115054
  2. Busatto S, Yang Y, Iannotta D, Davidovich I, Talmon Y, Wolfram J. Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays. J Extracell Vesicles. 2022 Apr;11(4):e12202. doi: 10.1002/jev2.12202. PMID: 35362268; PMCID: PMC8971175.
  3. Busatto S, Iannotta D, Walker SA, Di Marzio L, Wolfram J. A Simple and Quick Method for Loading Proteins in Extracellular Vesicles. Pharmaceuticals (Basel). 2021 Apr 13;14(4):356. doi: 10.3390/ph14040356. PMID: 33924377; PMCID: PMC8069621.
  4. Iannotta D, Yang M, Celia C, Di Marzio L, Wolfram J. Extracellular vesicle therapeutics from plasma and adipose tissue. Nano Today. 2021 Aug;39:101159. doi: 10.1016/j.nantod.2021.101159. Epub 2021 Apr 27. PMID: 33968157; PMCID: PMC8104307.
  5. Barone A, Cristiano MC, Cilurzo F, Locatelli M, Iannotta D, Di Marzio L, Celia C, Paolino D. Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids Surf B Biointerfaces. 2020 Sep;193:111152. doi: 10.1016/j.colsurfb.2020.111152. Epub 2020 May 25. PMID: 32535351.
  6. Wang X, Pham A, Kang L, Walker SA, Davidovich I, Iannotta D, TerKonda SP, Shapiro S, Talmon Y, Pham S, Wolfram J. Effects of Adipose-Derived Biogenic Nanoparticle-Associated microRNA-451a on Toll-like Receptor 4-Induced Cytokines. Pharmaceutics. 2021 Dec 22;14(1):16. doi: 10.3390/pharmaceutics14010016. PMID: 35056912; PMCID: PMC8780819.
Featured projects Duration
Development of hybrid nanosystems