Epigenetics and Genomic profiling
Yohaann Jafrani is a third year student undertaking their PhD in the Cheetham Lab at the AIBN. Yohaann’s work is supported by a UQ Graduate School Scholarship (UQGSS). Their research focuses on using DNA methylases to profile genomic interactions over time in single cells. Their work spans the fields of genomics, epigenetics and developmental biology. Before beginning their PhD Yohaann graduated with a Master’s in Molecular Biology from The University of Queensland in July 2020. During their Masters, they undertook multiple projects including investigating TorsinA function with Dr. Zacchi Lucia (SCMB/AIBN), profiling exosomal microRNAs with A/Prof Carlos Solomon (UQCCR) and identifying functional human pseudogenes with Dr. Seth Cheetham and Prof. Geoff Faulkner (Mater Research/TRI).
Funding
UQ Graduate School Scholarship (UQGSS) - 2020
Key Publications
Troskie, RL., Jafrani, Y., Mercer, T.R. et al. Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome. Genome Biol 22, 146 (2021). https://doi.org/10.1186/s13059-021-02369-0
Jonas Honer, Katie M. Niemeyer, Christian Fercher, Ana L. Diez Tissera, Noushin Jaberolansar, Yohaann M.A. Jafrani, Chun Zhou, Julio J. Caramelo, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Lucía F. Zacchi. TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1868, Issue 9, 2021, 119073, ISSN 0167-4889, https://doi.org/10.1016/j.bbamcr.2021.119073
Seth W. Cheetham, Yohaann M. A. Jafrani, Stacey B. Andersen, Natasha Jansz, Michaela Kindlova, Adam D. Ewing, Geoffrey J. Faulkner. Single-molecule simultaneous profiling of DNA methylation and DNA-protein interactions with Nanopore-DamID. bioRxiv 2021.08.09.455753; doi: https://doi.org/10.1101/2021.08.09.455753