Senescnece is an important driver of ageing related brain diseases. This project will use genetic and engineered brain organoid ageing models to identify and test better and more targetd senolytics and senomorphic compounds.
Systems that are flowing, conducting ions or electrcity, growing or changing with time are nonequilibrium systems. In fact, all real systems are out of equilbrium to some degree. Despite this, there is much to be learnt about how such systems behave at the molecular level.
Current mRNA therapeutics and vaccines are designed for high and ubiquitously translation. However, for many mRNA drugs and gene therapies the expression of the therapeutic RNA in all cells is undesirable and translational control must be tailored to the target tissue.
Directed self-assembly (DSA) is a type of directed assembly which utilizes block copolymer morphology to create lines, space and hole patterns, facilitating for a more accurate control of the feature shapes.
Per- and poly- fluoroalkyl substances (PFAS) are a group of man-made chemicals which can travel long distances through soil and water and do not break down in the environment.
Proteins are amongst the most important classes of therapeutic agents and have been widely used for the treatment of a variety of diseases including cancer. However, many proteins have poor solubility and stability, and often display high toxicity.
Despite the wide use of metal-based MRI contrast agents such as gadolinium chelates in the clinic, safety concerns have been raised regarding their potential toxic effects resulting from long-term in vivo retention.
