Single-molecule detection has opened an entirely new direction in life science research. The interaction between biomolecular components within a cell is complex and dynamic, with bulk analytical methods only able to provide averaging information, typically from multi-cellular samples.

Single-molecule, single-cell platforms can overcome this limitation and provide a deeper understanding of the dynamic behaviour of individual cells. Moreover, single molecule detection provides the required sensitivity needed to unravel complex and highly dynamic molecular circuits, along with the ability to visualise cellular heterogeneity.

This PhD project aims to develop an entirely new platform technology to visualise these complex and dynamic molecular circuits (e.g. signalling pathways) in real-time, and within any biological sample, from single cell extracts to enable a new generation of single-molecule sensitive platform and will be applied to understand molecular aberrations in cancer and immune overreactions.

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