A long-lasting oral drug delivery system using spiky silica nanoparticles

Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies.

This project aims to realise the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time.

Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, silica particles will be engineered with a spiky morphology as oral drug delivery vehicles, and their interactions at the bio-interfaces in gastrointestinal environment will be investigated in detail. The physicochemical properties of the spiky particles will be tailored to control their gastrointestinal transit time and fit desired pharmacokinetic profiles of a number of therapeutic drugs.

A versatile delivery platform will be thus established, and the safety profiles of these silica particulate formulations will also be assessed.

Successful completion of this project will generate new knowledge on the relationship between the physicochemical features of spiky silica nanoparticles and their gastric retention.

This project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.

Scholarship

This is an Earmarked scholarship project that aligns with a recently awarded Australian Government grant.

The scholarship includes:

• living stipend of $32,192 per annum tax free (2023 rate), indexed annually
• your tuition fees covered
• single overseas student health cover (OSHC).

Learn more about the Earmarked scholarship.

How to apply

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