Supervisor: Dr Amanda W. KijasĀ ( and Prof. Alan Rowan

The cells of the bone are uniquely isolated from other tissues in our body, contained within the hard, impermeable hydroxyapatite matrix. Where osteocytes, the master regulators of bone turnover are the longest living of the bone cells and are individually buried in small hydroxyapatite chambers. Employing a unique live 3D model system where both the biophysical and biochemical cues can be regulated, this project will unravel how these extracellular matrix properties of osteocytes can alter their signalling to other cells, controlling the constant and ongoing turnover of bone to maintain its integrity and repair.