Trau Group Honours Projects
Liquid biopsy approaches to improve treatment outcomes in brain cancer.
Supervisor Professor Matt Trau and Dr Richard Lobb
Glioblastoma (GBM) is an aggressive and invasive primary brain tumour originating in the central nervous system (CNS). The prognosis of GBM is very poor, with a median survival time of approximately 14 months. The rapid development of drug resistance and frequent local recurrence are key features contributing to poor patient outcomes. Accurate monitoring of GBM is difficult and depends on imaging modalities, such as magnetic resonance imaging (MRI). In this project, small extracellular vesicles (sEVs) secreted by GBM cells, in the size range of 50 – 150 nm, will used to develop a diagnostic and prognostic liquid biopsy approach to monitor GBM progression. Applicants can expect to engage in a multidisciplinary program of research involving molecular and cellular biology, sEV biology, and nanotechnology. All students interested in novel approaches to improving outcomes in brain cancer patients are encouraged to apply..
Engineering bionanoparticle systems for advanced therapeutic targeting.
Supervisor Professor Matt Trau and Dr Richard Lobb
Small extracellular vesicles (sEVs) are secreted by cells, facilitating intercellular communication by carrying cargo that reflects both their origin and destination. In this project, sEVs will be investigated for novel applications in therapeutic treatment of cancers as a safer and more effective alternative to existing liposome-based treatments. Applicants can expect to engage in a program of research involving molecular and cellular biology, protein engineering, and nanoparticle analysis. All students interested in novel approaches to treating cancer are encouraged to apply.
Group Leader: Professor Matt Trau
07 334 64173
m.trau@uq.edu.au
What to do
- Review each project description and find one which matches your areas of interest.
- Contact the research group leader or project advisor directly to discuss the project and arrange a meeting or visit to the AIBN lab.
Contact
If you have general enquiries about studying at AIBN please contact our HDR team.
hdr.aibn@enquire.uq.edu.au