Polyisocyanopeptide (PIC)-based hydrogel functionalised with tri-ethylene glycol is an ideal scaffold for wound healing approaches as it is a liquid that solidifies at body temperature enabling easy application to complex wound sites and their mechanical responsiveness mimics that of biopolymers. This project is focused on using PIC hydrogel as the matrix for therapeutic wound dressings and by conjugation of bioactive molecules, promote wound healing by bringing about hemostasis as well as disinfection and stimulation of subsequent healing.Bio-functionalised polyisocyanopetide based hydrogel for use in hemostasis (blood coagulation) the first stage of wound healing.