Nicolas is a structural biochemist interested in protein modelling, structure generation, protein engineering, and the dynamics of proteins/polymers
After completing a Biomedical Science degree at Queensland University of Technology (QUT), Nic went on to complete a PhD at QUT in the Cartilage Regeneration Laboratory. His PhD investigated the complex molecular structure of gelatin-based hydrogels and was completed at the end of 2022. Nic now uses his structural expertise to help with various projects in the Chappell group. This includes: antibody development, viral antigen characterisation, and the development of a membrane bound version of the molecular clamp.
Key Publications
Leahy D, Grant C, Jackson A, Duff A, Tardiota N, Van Haeften J, Chen X, Peake JM, Kruppa MD, Smith ET, Johnson DA, Lott WB, Harris JM. Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase. Molecules. 2021 Sep 2;26(17):5344. doi: 10.3390/molecules26175344. PMID: 34500777; PMCID: PMC8434204.
HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors
Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell
bioRxiv 2023.05.25.542289; doi: https://doi.org/10.1101/2023.05.25.542289
| Featured projects | Duration |
|---|---|
| Rapid Response Vaccine Pipeline | 2019–2024 |