Computational biophysics: membranes, membrane-protein interaction, and nanoparticle and polymer simulation

Dr Sheikh Imamul Hossain is working as a postdoctoral research fellow (molecular dynamics) at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at the University of Queensland. Previously, he completed his postdoctoral work at the University of Sydney, funded by the Australian Research Council (ARC) Centre of Excellence in Exciton Science and at the University of Technology Sydney (UTS).

A mathematician by training, he was awarded his PhD in computational biophysics from UTS in 2020 for his work on how nanoparticles interact with lung surfactant monolayers using Molecular Dynamics (MD) simulations. Post PhD, he worked on industry and ARC-funded projects to expand his computational fluid dynamics (CFD) and computational biophysics skills. His research mainly focuses on computational biophysics and materials, including membranes, membrane-protein interaction, polymers, interactions between small molecules with membranes, and nanoparticle simulation in biological environments.

Key Publications

Journal article: Phenolic compounds alter the ion permeability of phospholipid bilayers via specific lipid interactions
Sheikh I. Hossain, Suvash C. Saha, and Evelyne Deplazes
Physical Chemistry Chemical Physics Journal Article
DOI: 10.1039/D1CP03250J

Journal article: Computational Studies of Lipid-Wrapped Gold Nanoparticle Transport Through Model Lung Surfactant Monolayers Sheikh I. Hossain, Neha S. Gandhi, Zak E. Hughes, and Suvash C. Saha
The Journal of Physical Chemistry B 
DOI: 10.1021/acs.jpcb.0c09518

Journal article: Shape matters—the interaction of gold nanoparticles with model lung surfactant monolayers
Sheikh I. Hossain, Zhen Luo, Evelyne Deplazes, and Suvash C. Saha
Journal of The Royal Society Interface Journal Article
DOI: 10.1098/rsif.2021.0402

Journal article: The role of ion-lipid interactions and lipid packing in transient defects caused by phenolic compounds
Sheikh I. Hossain, M Seppelt, N Nguyen, C Stokes, Evelyne Deplazes
Biophysical Journal 121 (18), 3520-3532
DOI: 10.1016/j.bpj.2022.08.001

Journal article: Molecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutants (2019-06)Sheikh I. Hossain, Neha S. Gandhi, Zak E. Hughes, Y.T. Gu, and Suvash C. Saha
Biochimica et Biophysica Acta (BBA) - Biomembranes
DOI: 10.1016/j.bbamem.2019.06.001