O’Mara Group

Prof Megan O'Mara's highly interdisciplinary research lies at the interface of chemistry, biology, physics and computer science.

While our knowledge of structural biology, systems biology and omics data has expanded rapidly in the last few years, significant gaps remain in our understanding of how proteins, lipids and other biomolecules come together to bring about the molecular regulation of living cells. Megan uses multiscale simulations and high performance computing techniques to understand how the chemical environment of the cell influences function, and how biochemical changes resulting from inflammatory or disease processes change the cell's biophysical properties. She is particularly interested in how these changes can lead to differences in the efficacy of pharmaceuticals and the design of biocompatible molecules that will improve targeted drug delivery.

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