Dr Chang Lei specialises in nanotechnology-based biomarkers detection, advanced bone regeneration and dental applications.

​Dr Chang Lei has published 32 research articles including 2 book chapters, 89% of the publications in Q1 journals; 21% of the publications in the top 10% most cited publications worldwide. Her work has been cited by 228 organisations, 35 countries and in 26 research areas (Source: Web of Science & Scopus). Dr Chang Lei's research interests include nanotechnology-based biomarkers detection, advanced bone regeneration and dental applications. She has available projects "A Nano-platform for Affordable and Ultra-sensitive Bio-marker Detection" and "Silica bio-nanomaterials assisted stem cell differentiation for bone repair".

Dr Chang Lei completed her PhD in nanotechnology and bioengineering at The University of Queensland (UQ) in 2016 under the supervision of Professor Chengzhong Yu – a world leader in nanotechnology research.

After that, she took up a position as a Research Officer in AIBN. In 2017, She won the Advance Queensland research fellowship, which allowed her to continue her research in bio-analysis. In 2021, Dr Chang Lei is awarded the competitive UQ Amplify Fellow.

Industry

​The collaboration between Dr Chang Lei and Ellume Limited has successfully secured an Advance Queensland Fellowship and an ARC linkage project. Ellume owns the first FDA approved COVID-19 home Diagnostic test, Dr Lei is currently working with Ellume to develop the next generation of COVID-19 home test kit. 

Collaborations

​Dr Chang Lei has undertaken collaborative research with top scientists in Dentistry, Biomedical Science, Chemistry, Material and Medical Sciences both nationally and internationally (Prof. Saso Ivanovski and Prof. Chen Chen from The University of Queensland; Prof. Jiansheng Li from Nanjing University of Science and Technology; Prof. Minbo Lan from East China University of Science and Technology; Prof. Xing Long from Wuhan University).

Funding

​2021        UQ Amplify Fellow
2020        Australian Dental Research Foundation (ADRF) grant.
2019        Advance Qld Women's Research Assistance Program.
2019        UQ Amplify grant, The University of Queensland, Australia.
2017        Advanced Queensland Research Fellow (early career), Australia. 

Key Publications

​Gao, F.; Lei, C.*; Liu, Y.; Song, H.; Kong, Y. Q.; Wan, J. J.; Yu, C. Z*. Rational Design of Dendritic Mesoporous Silica Nanoparticles' Surface Chemistry for Quantum Dots Enrichment and Ultrasensitive Lateral Flow Immunoassay. ACS Appl. Mater. Interfaces2021, DOI: 10.1021/acsami.1c02149.

Gao, F.; Liu, Y.; Lei, C.*; Liu, C.; Song, H.; Gu, Z. Y.; Jiang, P.; Jing, S.; Wan, J. J.; Yu, C. Z*. The Role of Dendritic Mesoporous Silica Nanoparticles' Size for Quantum Dots Enrichment and Lateral Flow Immunoassay Performance. Small Methods, 2021, 5 (4), 2000924.

Lei, C.; Cao, Y. X.; Hosseinpour, S.; Gao, F.; Liu, J. Y.; Fu, J. Y.; Staples, R.; Ivanovski, S.; Xu, C. Hierarchical dual porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffold promote osteogenesis in vitro and in vivo. Nano Research2020, doi.org/10.1007/s12274-020-3112-2.

Li, H. M.; Guo, H. L.; Lei, C.; Liu, L.; Xu, L.Q.; Feng, Y. P.; Ke, J.; Fang, W.; Song, H.; Xu, C.; Yu, C. Z.; Long, X. Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Adv Mater201931 (46), 1904535. (Cover story)

Lei, C.; Noonan, O.; Jambhrunkara, S.; Qian, K.; Xu, C.; Zhang, J.; Nouwens, A.; Yu, C. Z. Sensitive Detection of Human Insulin Using a Designed Combined Pore Approach. Small2014, 10 (12), 2413-2418. 

Featured projects Duration
Sensitive Detection of Biomolecules
20132021