Nanoparticle-based Drug Delivery System

Fatemeh Movahedi’s research is to develop a new nanoplatform to efficiently deliver albendazole for cancer therapy. Initially recognised as an anti-parasitic drug, albendazole has recently emerged as an anticancer agent. However, the application is limited due to poor water solubility while formulating albendazole into nanoparticles is considered as a promising approach. Lipid-coated calcium phosphate (LCP) nanoparticles are a good  albendazole carrier and delivery vehicle due to biodegradability, biocompatibility and target capability. Her research is focused on optimising LCP nanoparticles to carry albendazole and enhancing the delivery efficacy in vitro and in vivo for cancer therapy.

Fatemeh Movahedi is currently doing her PhD under the supervision of Professor Zhi Ping (Gordon) Xu.

Key Publications

  1. Fatemeh Movahedi, Wenyi Gu, Zhi Ping Xu, Nanoformulations of albendazole as effective anti-cancer and anti-parasite agents, Nanomedicine, 2017.
  2. Christian Wiraja, Malathi Mathiyazhakan, Fatemeh Movahedi, Paul Upputuri, Yingying Cheng, Manojit Pramanik, Yang Liang, David Becker, Chenjie Xu, Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection, Bioengineering & Translational Medicine, 2016. 1(3):357-364.
  3. Fatemeh Movahedi, Rebecca Guomin Hu, David Laurence Becker, Chenjie Xu, Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics. Nanomedicine: Nanotechnology, Biology and Medicine 2015. 11(6):1575-1584.
  4. Fatemeh Movahedi, Hasan EbrahimiShahmabadi, Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Release modeling and comparison of nanoarchaeosomal, nanoliposomal and pegylated nanoliposomal carriers for paclitaxel,Tumor Biology 2014, 35(9):8665-8672.
  5. Hasan Ebrahimi Shahmabadi, Fatemeh Movahedi, Maedeh Koohi Moftakhari Esfahani, SeyedEbrahimAlavi, Ali Eslamifar, , GholamrezaMohammadi, Efficacy of Cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma.Tumor Biology 2014, 35(5):4799-4806. ​