Veronica Martinez specialises in the mammalian system biology field.

Her research focuses on the study of mammalian cell metabolism. She is specifically interested in (1) the development of computational tools for metabolic systems biology, and (2) the improvement of biopharmaceutical production processes. On the tools side, she has worked on the integration of thermodynamic principles and omics datasets into genome scale models to estimate metabolic flux distributions; and developed a method for estimation of dynamic metabolic fluxes. She has used these tools to describe experimental mammalian cells data and to guide the improvement of biopharmaceutical production processes. She has also been involved in the development of the latest human and CHO genome scale models. On the process side, she is currently working on the improvement of a high cell density culture, using systems biology tools to develop a cell line adapted to high cell density and to develop an improved upstream bioprocess.

​Dr Veronica is  a Postdoctoral Research Fellow at the ARC Training Centre for Biopharmaceutical Innovation (CBI), under the supervision of Professor Steve Mahler. She received her Biotechnology Engineering degree at the University of Chile in 2007, and completed her PhD in Systems Biology at The University of Queensland in 2014. After completing her PhD she performed 2 years of postdoctoral training at The University of Queensland, as part of a collaboration project with Universidad de Chile. Both Ph.D. studies and postdoctoral training were financially supported by the Chilean Government, under a competitive scholarship and fellowship, respectively. She has also performed tutorial teaching in several courses at Universidad de Chile and University of Queensland. In 2016 she was in charge of the Beer and Biofuels practical,  part of the subject: Biomolecular Engineering (CHEE4020) of the chemical engineering department at The University of Queensland.  

Collaborations

Veronica current position is in a collaboration project between CBI and Patheon.

Key Publications

Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jimenez NE, Zielinski DD, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE. (2016) A consensus genome-scale reconstruction of CHO cell metabolism for improved biotherapeutic protein production. Cell Systems, 3(5):434-443.e8.

Swainston N, Smallbone K, Hefzi H, Dobson PD, Brewer J, Hanscho M, Zielinski DC, Ang KS, Gardiner NJ, Gutierrez JM, Kyriakopoulos S, Lakshmanan M, Li SZ, Liu JK, Martinez VS, Orellana CA, Quek LE, Thomas A, Zanghellini J, Borth N, Lee DY, Nielsen LK, Kell DB, Lewis NE, Mendes P. (2016) Recon 2.2: from reconstruction tomodel of human metabolism. Metabolomics, 12(7).

Martínez VS, Quek LE, Nielsen LK. (2014). Network thermodynamic curation of human and yeast genome-scale metabolic models. Biophysical Journal, 107: 493-503.

Martínez VS, Dietmair S, Quek LE, Hodson MP, Gray P, Nielsen LK. (2013) Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnology and Bioengineering, 110(2):660-666.

Martínez V, Gerdtzen ZP, Andrews BA & Asenjo J. (2010) Viral Vectors for the treatments of alcoholism: Use of metabolic flux analysis for cell cultivation and vector production, Metabolic Engineering, 12, 129-137.