Research Focus

The Marcellin Group, led by Group Leader Dr Esteban Marcellin, is dedicated to developing systems metabolic engineering toolboxes, with the goal of better understanding biological cells to enhance the production of fuels, chemicals and biopharmaceuticals. Systems metabolic engineering incorporates the concepts and techniques of systems biology, synthetic biology and bioprocess optimisation, offering a framework to modify pathways and bioprocesses for the optimal bioproduction of desired products.

Characterising cells at the molecular level to efficiently manufacture natural and non-natural bioproducts is possible through multi-omics data integration using computational models. The Group’s research aims to integrate multi-omics data to accelerate the design of cells into efficient biological factories.

The Group has recently established a state-of-the-art gas fermentation facility, unique in Australia, which enables fermenting methane and syngas in instrumented fermenters.