Cory's PhD focuses on combining clinical and wet lab work (face-to-face patient research and assessment of human samples/biofluids) with dry lab work (advanced statistical approaches) to decipher the heterogeneity of MND, and developing tools for the remote monitoring of patients outside traditional clinical settings.
Cory completed his honours in the Ngo lab during which he investigated the use of biomarkers for tracking disease progression in people living with MND. Following his honours, Cory continued in the lab as a research assistant, strengthening clinical research ties with collaborators in Utrecht, Netherlands. In 2020, Cory commenced his PhD at the AIBN.
Funding
2022: Holdom, Ngo*, Steyn*, ActiGraph Digital Endpoint Accelerator Research Grant (10,000 USD)
Key Publications
Holdom CJ, van Unnik JWJ, van Eijk RPA, van den Berg LH, Henderson RD, *Ngo ST, *Steyn FJ. “Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease”. Journal of Neurology. 2023. https://doi.org/10.1007/s00415-023-11584-7
Chang J, Shaw TB, Holdom CJ, McCombe PA, Henderson RD, Fripp J, Barth M, Guo CC, Ngo ST, Steyn FJ. “Lower Hypothalamic Volume with Lower BMI is Associated with Shorter Survival in Patients with ALS”. European Journal of Neurology. 2023. https://doi.org/10.1111/ene.15589
Helleman J, Johnson B, Holdom CJ, Hobson E, Murry D, Steyn FJ, Ngo ST, Henders A, Lokeshappa MB, Visser-Melley JMA, van den Berg LH, Hardiman O, Beelen A, McDermott C, van Eijk RPA. “Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey”. Journal of Neurology. 2022. https://doi.org/10.1007/s00415-022-11273-x
Holdom CJ, Rogers M-L, Steyn FJ, Ngo ST. “Biofluid biomarkers of amyotrophic lateral sclerosis”. Towards Translating Biomarker Research of Neurodegenerative Diseases to Clinical Practice: Neurodegenerative diseases biomarkers. 11. p263-306. Invited book chapter. Springer. 2022. https://doi.org/10.1007/978-1-0716-1712-0_11
Holdom CJ, Janse van Mantgem MR, van Eijk RPA, Howe SL, van den Berg LH, McCombe PA, Henderson RD, Ngo ST*, Steyn FJ*. “Venous creatinine as a biomarker for loss of fat-free mass and progression in patients with Amyotrophic Lateral Sclerosis”. European Journal of Neurology. 2021. https://doi.org/10.1111/ene.15003
| Featured projects | Duration |
|---|---|
| Metabolic dynamics in human MND | 2015–2025 |