The development of effective therapeutics that target chronic pain in neurological diseases would significantly improve the quality of life for millions of people living with chronic pain. The glycinergic neuronal transport proteins are a promising target for the treatment of chronic pain.
Biocompatible delivery systems allow enhanced delivery of pharmaceuticals, vaccines and other biological payload molecules, with varied effects including extending the pharmaceutical half-life of drugs, increasing adsorption and decreasing immunogenicity.
Multidrug resistant (MDR) infections are a global healthcare crisis. In Staphylococcus aureus and several other clinical pathogens, resistance has emerged to all classes of antimicrobial agents, including antibiotics and hospital-grade antiseptics.
What makes a leader? The person with the loudest voice? An unmatched drive to be seen and heard? PhD scholar Nyakuoy Yak says there's no reason it can't be someone sitting quietly behind a microscope.
While we know that DNA mutations in the tRNA synthase gene DARS cause the pathology, the precise molecular and cellular processes that underlie this leukodystrophy remain unclear and no effective therapeutics exist.
This consumer-driven project will leverage brain organoid models derived from hIPSC lines from patients with the genetic hereditary spastic paraplegia SPG56 to test the safety and efficacy of viral gene delivery therapy.
Ataxia-Telangiectasia (A-T) is caused by mutations in the ATM kinase, a protein involved in DNA break repair, oxidative stress regulation and metabolism.
Replacing a defective gene via AAV mediated gene therapy is a powerful therapeutic approach. This project will develop and test safer gene therapy approaches in pre-clinical human brain organoid models.
For those interested in: stem cell ageing and regenerative engineering
Human brain development can be severely impacted by a lack of oxygen perinatally. This project will study the molecular and cellular processes that are responsible in human stem cell derived brain organoid models.
For those interested in: Stem cell ageing and regenerative engineering
